Fig. 2.1 Conformational change within β2GPI. (A) β2GPI as it circulates in plasma. (B) Binding to negatively charged phospholipids opens up β2GPI. (C) Binding of autoantibodies stabilizes β2GPI in its…
© Springer International Publishing AG 2017Doruk Erkan and Michael D. Lockshin (eds.)Antiphospholipid Syndrome10.1007/978-3-319-55442-6_12 12. Prevention and Treatment of Obstetric Antiphospholipid Syndrome Guilherme Ramires de Jesús1 , Karen J. Gibbins2, Robert M. Silver3 and D. Ware Branch4 (1) Department of Obstetrics, Hospital Universitario Pedro Ernesto, Universidade…
Test Cutoff Sensitivity (%) Specificity (%) OR (95%CI) aPL score APTT mixing confirmation test, ratio >49s 39.1 89.3 5.36(2.53–11.4 5 >1.3 19.6 95.2 4.81(1.79–12.9) 2 >1.1 30.4 90.9 4.38(1.96–9.76) 1…
Cardiovascular disease and venous thrombosis prevention Screening for and aggressive management of conventional atherosclerosis risk factors Screening for and elimination of venous thrombosis risk factors Patient education Primary thrombosis prevention…
Manifestations Strength of evidence Stroke/transient ischemic attack Strong association based on large sample size prospective studies Cognitive dysfunction Migraine Seizure/epilepsy Frequently reported but based on small sample size prospective studies…
© Springer International Publishing AG 2017Doruk Erkan and Michael D. Lockshin (eds.)Antiphospholipid Syndrome10.1007/978-3-319-55442-6_8 8. Clinical and Prognostic Significance of Non-criteria Antiphospholipid Antibody Tests Maria Laura Bertolaccini1 , Olga Amengual12, Bahar Artim-Eser13, Tatsuya Atsumi14, Philip G. de Groot15, Bas de Laat16, Katrien M. J. Devreese17, Ian Giles18, Pier Luigi Meroni19, Maria Orietta Borghi3, Anisur Rahman4, Jacob Rand5,…
Mouse model Comments Features of APS Production of aPL MRL/Mp-lpr/lpr (MRL/lpr) [2] – Yes Yes MRL-lpr/lpr (MRL/+) [2] – Yes Yes NZB [3] – Yes Yes BXSB-Yaa [4] Features are…
Years Advances 1 1906–1962 Identifying an antigen, associating the antibody with systemic lupus erythematosus 2 1952–1980 Defining lupus anticoagulant, understanding a mechanism 3 1969–1985 Defining and measuring anticardiolipin 4…
