Surface Epithelial Tumours of the Ovary
Fig. 4.1 Serous tubal intraepithelial carcinoma (STIC) at the fimbrial end of the Fallopian tube; the epithelial cells show enlarged and atypical nuclei with formation of tufts While the concept…
Pathology of Non-epithelial Malignancies of the Ovary
Germ cell tumours Dysgerminoma Variant With syncytiotrophoblastic cells Yolk sac tumours Variants Polyvesicular vitelline Hepatoid Glandular Embryonal carcinoma Polyembryoma Choriocarcinoma, non-gestational Teratoma Immature Mature Solid Cystic (dermoid cyst): With secondary…
Diagnosis and Management of Epithelial Ovarian Cancer with Peritoneal Metastases
Fig. 11.1 The peritoneal cancer index uses the distribution of cancer implants throughout the abdomen and pelvis combined with a lesion size of these nodules in order to quantitate the…
Treatment of Advanced Stage Ovarian Cancer
Stage I: Growth limited to the ovaries IA: Tumour limited to one ovary; capsule intact, no tumour on ovarian surface; no malignant cells in ascites or peritoneal washings IIB: Tumour…
Quality of Life in Patients with Ovarian Cancer
Fig. 14.1 Conceptual model of QOL in ovarian cancer (Adapted from Kornblith et al. [2] and [3]) As recognition of the importance of QOL as a patient-centered outcome has increased…
Targeted Molecular Therapy for Patients with Ovarian Cancer
Fig. 12.1 Mediators of tumor angiogenesis Antiangiogenic Agents Bevacizumab Bevacizumab is a recombinant, humanized, monoclonal immunoglobulin G1 antibody targeted at VEGF-A, which is approved for the treatment of metastatic colorectal…
Ovarian Cancer in the Pediatric Population
Fig. 8.1 Distribution of tumor histopathology shown as a percentage of total ovarian tumors in SEER database study (From Brookfield et al. [4]; with permission) Table 8.1 Histologic classification of…
Ovarian Cancer Screening and Early Detection
Biomarker Description Method Reference CA 15-3 Tumor antigen Serum ELISA Woolas et al. [41] CA 19-9 Tumor antigen Serum ELISA Woolas et al. [41] TAG-72 Tumor antigen Serum ELISA Woolas…
Management of Patients with Early-Stage Ovarian Cancer
Professional group Recommendation US Preventive Services Task Force Does not recommend routine screening, concluding that “the potential harms outweigh the potential benefits” American Cancer Society Does not recommend routine screening;…
Psychological Aspects of Hereditary and Non-hereditary Ovarian Cancer
Level of evidence Factor Most frequently observed observation Strong Age Younger age—more distress Disease stage More advanced disease—more distress Time since diagnosis Shorter—more distress Disability status Worse—more distress Physical symptoms…
