Panniculitis-Like Reactions Amanda J. Shelley Katherine A. McDonald Anna Kristine Dewan Panniculitis is an uncommon reaction that may occur secondary to cytotoxic chemotherapy, immune checkpoint inhibitors, or small molecule inhibitors….
Bullous Reactions Rohit Gupta Anisha B. Patel Bullous reactions represent a group of skin toxicities characterized by fluid-filled vesicles or bullae with varying localized or diffuse presentations depending on the…
Intertriginous Reactions Rachel Reingold Alina Markova An intertriginous reaction pattern may present as erythematous, desquamative, scaly, dusky or eroded patches or plaques commonly affecting one or more folds in the…
Acneiform Reactions Michelle S. Lee Vinod E. Nambudiri Acneiform eruptions are a relatively common skin toxicity, occurring across several drug classes, and are observed in up to 80% of patients…
Psoriasiform Reactions Jordan Taylor Said Jennifer T. Huang Psoriasiform reactions are a specific subset of papulosquamous skin toxicities, thought to be induced by chemotherapy agents that impact keratinocyte proliferation, differentiation,…
Morbilliform Reactions Connie R. Shi Steven T. Chen Morbilliform eruptions, or exanthematous eruptions, present with numerous erythematous, blanching, nonscaly 3 to 4-mm papules that can coalesce into larger plaques most…
Reactions in Patients with Skin of Color Oyetewa Oyerinde Michelle S. Lee Jennifer Y. Lin As is the case for the full spectrum of dermatologic disease, manifestations of cutaneous toxicity…
Highlights • Small molecule MIF inhibitor CPSI-1306 inhibits HNSCC growth in vivo . • CPSI-1306 potently inhibits T cell immunosuppression in the tumor microenvironment. • CPSI-1306 completely abrogates CTLA4, TIGIT…
Highlights • The immune TME in NPC is unsupervisedly dissected into “Immune Inflamed” and “Immune Deficient” subtypes. • Tertiary lymphoid structures (TLS) serve as better prognostic indicators than individual immune…
Highlights • ctDNA provided complementary information on actionable mutations to tissue biopsy. • ctDNA provided a comprehensive view of mutational landscape dynamics over time. • ctDNA-based molecular relapse detection has…
