Adjuvant Endocrine Therapy
Abstract Endocrine therapy is a key component of the adjuvant treatment of early-stage breast cancer. In this chapter, we review the current approach to adjuvant endocrine therapy for early-stage invasive…
ONCOLOGY
Radiation Therapy for Locally Advanced Breast Cancer: Historical Review to Current Approach
Abstract This chapter describes the evolution of therapy for locally advanced breast cancer. Optimal management requires coordinated multidisciplinary care. Current treatment paradigms for LABC include use of neoadjuvant chemotherapy; resection,…
Adjuvant and Neoadjuvant Systemic Therapies for Early-Stage Breast Cancer
Abstract Background: While surgery is still the cornerstone treatment for early stage breast cancer, a deeper understanding in breast cancer biology has led to improvements in systemic therapies that improve…
Lymphedema in the Postmastectomy Patient: Pathophysiology, Prevention, and Management
Abstract Lymphedema is the most dreaded complication of breast cancer surgery. It may result in functional, esthetic, and psychological problems, thereby affecting the quality of life of the breast cancer…
Partial Breast Irradiation: Accelerated and Intraoperative
Abstract Partial breast irradiation encompasses a variety of techniques including accelerated partial breast irradiation (APBI) and intraoperative radiation therapy (IORT). APBI includes multicatheter brachytherapy, applicator based brachytherapy, and external-beam techniques….
Breast Conserving Therapy for Invasive Breast Cancers
Abstract The combination of breast conservation surgery (BCS) and whole breast radiation therapy (WBRT) is an effective alternative to mastectomy for the majority of women with early-stage invasive breast cancer,…
Biological Basis of Radiotherapy of the Breast
Abstract Radiation therapy is commonly used in early-stage breast cancer treatment but must be delivered carefully to minimize the risks to critical adjacent structures, such as the heart and lung….
Postmastectomy Radiotherapy
Abstract Postmastectomy radiotherapy (PMRT) is an integral component of the multimodal treatment of invasive breast cancer in patients with sufficient risk of harboring a reservoir of locoregional disease despite mastectomy…
Radiotherapy and Ductal Carcinoma in Situ
Abstract Multiple retrospective studies and prospective randomized trials have clearly established the long-term efficacy of breast conserving surgery and radiotherapy in the management of patients with DCIS. Radiation therapy has…
Breast Imaging Screening and Diagnosis
Abstract This chapter reviews the most commonly used imaging modalities in the screening and diagnosis of breast diseases. Topics discussed include characteristic benign and malignant imaging findings on mammography, breast…
