Hair and Nail Abnormalities Jennifer E. Yeh Jennifer T. Huang HAIR CHANGES Hair loss is one of the most common and distressing side effects of cancer treatment and can be…

Radiation Recall Stephanie W. Liu Radiation recall is an inflammatory skin reaction that occurs in a previously irradiated field. The recall is triggered by administration of certain pharmacologic agents sometime…

Mucositis Shikha Walia Jennifer Nam Choi CYTOTOXIC CHEMOTHERAPY AND RADIATION In the context of anticancer therapy, the oral mucosa is a commonly involved site of inflammation, ulceration, and potential subsequent…

Oral Toxicities Shaiba Sandhu Brittany A. Klein Sook Bin Woo Nathaniel Treister Herve Y. Sroussi Oral mucosal toxicities are a common finding in patients treated with a range of anticancer…

Reactions on the Hands and Feet Louise M. Gresham Maxwell B. Sauder Toxicities from anticancer therapies affecting the hands and feet are common and can be divided into three main…

Pigmentary Alterations Amina Bougrine Pigmentary alterations caused by anticancer therapies can be seen in any phototype but are more frequent and prolonged in darker phototypes. They are rarely specific to…

Sclerosing Reactions Jordan Taylor Said Cecilia Alejandra Larocca Sclerosing reactions are a rare set of cutaneous toxicities that can be caused by chemotherapy, immunotherapy, and radiotherapy—each with a unique presentation….

Edematous Reactions Jared Seth Kahn David X. Gao Sandhya Deverapalli Edema occurs when there is a pathologic accumulation of fluid in either the interstitial spaces or an intracellular compartment. Various…

Erythroderma Michelle S. Lee Vinod E. Nambudiri Erythroderma is typically defined as diffuse redness affecting over 80% to 90% of the body’s surface area (Figure 11.1). It is a reaction…

Purpuric Reactions Jasmine Rana Bernice Y. Kwong Purpura is due to red blood cells extravasating into the skin or mucous membranes. Purpuric lesions present as deep red to purple in…