CCR4 Inhibitors
CCR4 Inhibitors Cesar Antonio Virgen Cecelia Alejandra Larocca Mogamulizumab is the only FDA-approved C-C chemokine receptor type 4 (CCR4) inhibitor. It is approved for the treatment of relapsed or refractory…
ONCOLOGY
Hormonal Therapies
Hormonal Therapies Jane J. Han Lauren M. Guggina Hormones, such as estrogen and androgens, are important in the initiation and proliferation of endocrine-sensitive cancers. Therefore, hormonal therapy is commonly used…
Proteasome Inhibitors
Proteasome Inhibitors Abdulhadi Jfri Victor Huang Ian W. Tattersall Proteasome inhibitors are a group of agents that inhibit the ubiquitin proteasome pathway, which regulates multiple cellular processes, including cell growth…
Fibroblast Growth Factor Receptor (FGFR) Inhibitors
Fibroblast Growth Factor Receptor (FGFR) Inhibitors Catherine Pisano Christopher Iriarte Nicole R. LeBoeuf Fibroblast growth factors (FGFs) and their receptors (FGFRs) play an important role in normal cell biology, including…
BCR/ABL/C-Kit Inhibitors
BCR/ABL/C-Kit Inhibitors Catherina X. Pan Vinod E. Nambudiri The B-cell receptor (BCR) pathway is a complex signaling cascade involved in B-cell activation, whose aberrant activation leads to leukemias and lymphomas.1…
BTK Inhibitors
BTK Inhibitors Blake Elizabeth Brooks Elisa M. Schunkert Sherrie J. Divito Bruton tyrosine kinase (BTK) is a cytoplasmic nonreceptor tyrosine kinase that plays an integral role in signal transduction of…
Multikinase Inhibitors
Multikinase Inhibitors Karolina Mieczkowska Beth McLellan Multikinase inhibitors (MKIs) represent a diverse array of targeted chemotherapies (Table 33.1) that are used in the treatment of both solid and hematologic malignancies….
mTOR Inhibitors
mTOR Inhibitors Adam Faletsky Shaiba Sandhu Herve Y. Sroussi Lauren M. Guggina The mammalian target of rapamycin (mTOR) is an important factor in cell growth and survival. mTOR is a…
PI3-Kinase Inhibitors
PI3-Kinase Inhibitors Shaiba Sandhu Ashleigh Eberly Puleo Nicole R. LeBoeuf The phosphoinositide 3-kinase (PI3K) pathway is important in cell survival, proliferation, and differentiation1 and is frequently altered in human cancers;…
MEK Inhibitors
MEK Inhibitors Michael S. Chang Rebecca I. Hartman The mitogen-activated protein kinase (MAPK) pathway is highly implicated in aberrant signaling leading to carcinogenesis. Primary targets of this signaling cascade include…
