Cancer Complications TUMOR LYSIS SYNDROME Jarett L. Feldman Matthew J. Matasar Definition TLS is the metabolic abnormalities a/w spontaneous &/or tx-induced cell death that can be potentially fatal in certain…

Cancer Pharmacology PHARMACOGENETICS AND PHARMACOGENOMICS Mabel Rodriguez Introduction Pharmacogenetics: Effect of heritability on response to drugs. Study of single genes & their effects on interindividual differences in drug metabolizing enzymes….

Cancer Genetics BRCA1/2 Payal D. Shah Kenneth Offit Mark Robson Biology Genes: BRCA1 on chromosome 17q, BRCA2 on 13q Function: TSGs; proteins function in double-stranded DNA damage repair by homologous…

Cancer Immunology CANCER IMMUNOBIOLOGY Gabriela Soriano Hobbs Alexander M. Lesokhin Cancer Immunology Basics The immune system plays an important role in CA surveillance; Rx that modulate & amplify the immune…

Cancer Biology CANCER HALLMARKS & STEM CELLS Alexander Drilon Hallmarks of Cancer CAs share a set of common distinctive & complementary capabilities that enable tumor growth & met dissemination (Cell…

Molecular Diagnostics SEQUENCING Chung-Han Lee Classic Sanger Sequencing Developed in 1977 by Frederick Sanger & colleagues Required reagents DNA template (what you want to seq) DNA primer (known seq) dNTPs…

Radiation Oncology BASIC RADIATION BIOLOGY AND PHYSICS Gaorav P. Gupta Barry S. Rosenstein Definitions Ionizing Radiation (IR): Photons that have adequate energy to eject orbital electrons from target molecules X-rays:…

Clinical Research Methods PHASE I CLINICAL TRIALS Connie Lee Batlevi David R. Spriggs Phase 0 Trials Proof of concept trials designed to be first in human (Nat Rev Cancer 2007;7:131)…

General Oncology CANCER EPIDEMIOLOGY Anita Kumar Victoria Blinder Cancer Epidemiology Research Methods Epidemiology: Study of distribution, determinants, & outcomes of cancer at a population level; applies public health or policy…