Carcinomas of the Head and Neck
Carcinomas of the Head and Neck Frank E. Mott Ibrahim Ebada Sadek Josh David Simmons I. INTRODUCTION Data from the National Cancer Institute’s SEER (Surveillance, Epidemiology, and End Results) program…
ONCOLOGY
Selection of Treatment for the Patient With Cancer
Selection of Treatment for the Patient With Cancer Roland T. Skeel I. SETTING TREATMENT GOALS A. Patient perspective Although patients most often come to the physician looking for medical perspective…
Systematic Assessment of the Patient With Cancer and Consequences of Treatment
Systematic Assessment of the Patient With Cancer and Consequences of Treatment Roland T. Skeel I. ESTABLISHING THE DIAGNOSIS A. Pathologic diagnosis is critical Although it might seem obvious that the…
Principles of Cancer Immunotherapy
Principles of Cancer Immunotherapy Mario Sznol I. INTRODUCTION Agents that produce anticancer activity through one or more components of the immune system play an important and, in some cases, a…
Biologic Basis of Molecular Targeted Therapy
Biologic Basis of Molecular Targeted Therapy Osama E. Rahma Paul R. Kunk Samir N. Khleif I. INTRODUCTION Molecular targeted therapy (MTT) is a new approach to cancer treatment that resulted…
Biologic and Pharmacologic Basis of Cancer Chemotherapy
Biologic and Pharmacologic Basis of Cancer Chemotherapy Roland T. Skeel I. GENERAL MECHANISMS BY WHICH CHEMOTHERAPEUTIC AGENTS CONTROL CANCER The purpose of treating cancer with chemotherapeutic agents, whether traditional or…
Methylation Alterations in Multiple Myeloma as a Model for Epigenetic Changes in Cancer
TABLE 2 | Methylation implicated in malignant transformation of monoclonal gammopathy of uncertain significance (MGUS) to Multiple Myeloma (MM) P16 (CDKN2A) P16 is an inhibitor of cyclin-dependent kinases (CDKs) and…
High-Throughput Arrays for Relative Methylation (CHARM)
Figure 20.1.1 Overview of McrBC-based fractionation (Lippman et al., 2005; Ordway et al., 2006) coupled with CHARM analysis (Irizarry et al., 2008). Genomic DNA is sheared to 1.5 to 3.0…
and dynamics of DNA methylation
FIGURE 1 | Cell type specificity of DNA methylation. This figure shows the dissimilarity of cell types based on their methylation frequencies from targeted bisulfite data that covered CpG islands…
