Clinical scenario Recommendations Level of evidenceb Primary thromboprophylaxis Not recommended (including LMWH, warfarin, FFP) 1B Routine screening with coagulation studies or for thrombophilia not recommended 2C Thrombophilia screening can be…
Clinical status Description Hemoglobin level for transfusion (g/dL) Level of evidencea Stable Asymptomatic, imminent marrow recovery <7 1C Vital sign changes Tachycardia, tachypnea, hypotension <8 1C Thrombocytopenia Recent or active…
Disease Potential side effect Treatment Level of evidenceb Acute lymphoblastic leukemia Leukostasis Rapid initiation of chemotherapy 1A Hyperhydration 1C Consider leukapheresis for WBC >400–600 × 109/L if no delay in antileukemic chemotherapy…
Laboratory tumor lysis syndrome (2 or more of the following occurring from 3 days prior up to 7 days after commencement of cytotoxic therapy) Uric acid ≥8 mg/dL or 25…
Fig. 1 Validation trial #1 main hospital specimens Fig. 2 TissueSAFE histologic assessment of morphologic preservation 2 Validation Trial #2—Defining the Transport System from Community Hospital One of our chief goals was…
The same lack of technical improvements applies to various different steps along the histopathological processing. Tissue fixation is still conducted manually and with the use of formaldehyde originally proposed by…
Fig. 1 Morphological evaluation of two differently processed parts of a bone marrow trephine biopsy (H&E). a, c Fixation in 10 % neutral buffered formalin (NBF) at room temperature (RT) for at…
Fig. 1 ×200 image of a 4-mm-thick human tonsil section placed directly into 40 °C 10 % neutral buffered formalin for 1 h. Sample is stained with hematoxylin and eosin to reveal tissue morphology…
Indications and contraindications for a frozen section in mammapathology Applicable Non-applicable Clarification of dignity in preoperative uncertain situations (e.g., multicentricity) + Clarification of representativeness (dense breast parenchyma, dislocation of wire…
Rapid MW protocol logos™ (1 h 39 min) Reagent Time Phase T °C Pressure (mBar) Formalin 10 % NBF 25′ 1 = 10′ 50° 2 = 15′ Ethanol 60° 2′ Ethanol 99° 3′ Ethanol 99° 16′ 1 = 8′ 65° …
