© Springer New York 2015Grace A. Mucci and Lilibeth R. Torno (eds.)Handbook of Long Term Care of The Childhood Cancer SurvivorSpecialty Topics in Pediatric Neuropsychology10.1007/978-1-4899-7584-3_19 19. Cultural and Linguistic Issues in the Assessment and Treatment…
Medical History: Anna was treated at age 3 for Acute Lymphoblastic Leukemia with chemotherapy and cranial radiation known to affect cognitive function in later-life. At age 26, Anna is referred…
Fig. 1.1 Major transitions associated with cancer treatment. Reproduced with permission from MacLean et al. Cancer 1996; 78(6) For some patients, transition may also include development of relapse, and, for…
Chemotherapy Dose Late effect Baseline screening Anthracycline ≥300 mg/m2 or Cardiomyopathy valvular, pericardial damage, coronary artery disease EKG, ECHO (Doxorubicin >200 mg/m2 + Daunorubicin Chest XRT ≥30 Gy Epirubicin HD…
Study GWAS vs. candidate gene Study design Replication Sample size Results Therapy-related leukemia-associated with exposure to alkylating agents and topoisomerase II inhibitors Genome-wide association studies Knight et al. 2009 [90]…
Question Response Did the patient have any of the following tumor types: neuroblastoma, brain tumor, germ cell tumor, osteosarcoma, hepatoblastoma? □ Yes □ No Did the patient receive cisplatin chemotherapy?…
Cancer treatment risk factor Potential late effect Additional risk factors Recommended evaluation Evidence scorea Mercaptopurine Thioguanine Veno-occlusive disease (VOD) Viral hepatitis Screening 2A Prior VOD Siderosis Mercaptopurine Thioguanine Methotrexate Hepatic…
Stage N Treatment 6-Year EFS% 6-Year survival 1 41 S + BEP 95 95.1 2 16 S + BEP 87.5 93.8 3 58 S + HDP/EB vs. BEP 96.6 97.3 4 16 S + HDP/EB vs. BEP 86.7…
Fig. 8.1 Mechanisms of pulmonary dysfunction and/or growth by hematopoietic stem cell transplantation (HSCT). BO bronchiolitis obliterans, BOOP bronchiolitis obliterans organizing pneumonia, DAH diffuse alveolar hemorrhage, IPS idiopathic pneumonia syndroma…
Function Complication Therapy-related risks Relationship to time, dose to gland or organ when applicable Linear Growth GH deficiency Surgery Damage to the pituitary by tumor expansion and/or surgery Radiotherapy to…
