Notch Pathway
(1) Institut Bergonié, Bordeaux, France Abstract The Notch pathway, as the Wnt–β-catenin pathway, is an important signalling pathway in vertebrate and invertebrate development. It is involved in embryogenesis and…
ONCOLOGY
Hedgehog Pathway
(1) Institut Bergonié, Bordeaux, France Abstract The Hedgehog pathway is an important signalling pathway for the development of vertebrates and invertebrates. It is involved in embryogenesis and morphogenesis and…
Cytokines Pathway
(1) Institut Bergonié, Bordeaux, France Abstract An important group of signalling molecules operate through a pathway which is slightly different from that described in Chap. 1: their receptors do…
Wnt Pathway
(1) Institut Bergonié, Bordeaux, France Abstract The term Wnt was forged by contraction of Win gless-type mouse mammary tumour virus int egration site after the discovery on a viral…
TGFβ Pathway
(1) Institut Bergonié, Bordeaux, France Abstract Transforming growth factor beta (TGFβ) is the lead of a large family of factors studied in this chapter, which comprise several stricto sensu…
Metabolic Emergencies in Oncology
Metabolic Emergencies in Oncology Ephraim Paul Hochberg INTRODUCTION Metabolic emergencies represent rare events in the care of cancer patients. In contrast to the measured pace of most of oncology, these…
Molecular Targeted Drugs
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Myeloproliferative Neoplasms
Myeloproliferative Neoplasms Jerry L. Spivak POLYCYTHEMIA VERA INTRODUCTION Polycythemia vera (PV) is a clonal disorder of a multipotent hematopoietic stem cell in which overproduction of morphologically normal red cells, white…
Peripheral T-cell Lymphomas
Peripheral T-cell Lymphomas Jeffrey A. Barnes, Jeremy S. Abramson INTRODUCTION The peripheral T-cell lymphomas are a heterogeneous group of lymphoid malignancies each with a distinct clinical presentation and prognosis. The…
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Philip C. Amrein INTRODUCTION Chronic lymphocytic leukemia (CLL) is a neoplastic disease characterized by the accumulation of monoclonal lymphocytes in blood, bone marrow, and lymphoid…
