Thymoma Panos Fidias INTRODUCTION Thymoma is a rare disease, with an incidence of only 0.13 per 100,000 person-years (1). However, it is the most common tumor of the anterior mediastinum,…

Primary Squamous Carcinoma of the Uterine Cervix: Diagnosis and Management Olivia Foley, Marcela G. del Carmen INTRODUCTION Squamous cell carcinoma of the uterine cervix comprises an estimated 80% of all…

Diffuse Large B-Cell Lympho Jennifer Gao, Ephraim Paul Hochberg Lymphomas are a malignancy arising from lymphoid cells, with more than 60 distinct variants identified by the World Health Organization (WHO)….

Depression, Anxiety, and Fatigue Carlos G. Fernandez-Robles, William F. Pirl INTRODUCTION Depression, anxiety, and fatigue are frequent complications of cancer and cancer treatment. Although fatigue can be caused by depression…

Immunomodulatory Drugs and Proteasome Inhibitors Anuj Mahindra, Hamza Mujagic, Bruce A. Chabner The therapeutic options for the treatment of multiple myeloma (MM) have expanded over the past decade with the…

Adduct-Forming Agents: Alkylating Agents and Platinum Analogs Bruce A. Chabner Since the first clinical experiments with nitrogen mustard at Yale in the early 1940s, alkylating agents have played a primary…

Febrile Neutropenia Stephen M. Carpenter, Fabrizio Vianello, Mark C. Poznansky INTRODUCTION Immune-compromised state refers to a change of the host defense systems that confer an increased susceptibility to infection. Neutropenia…

Acute Lymphoblastic Leukemia and Lymphoma James W. Fraser, Janet E. Murphy, Eyal C. Attar INTRODUCTION Acute lymphoblastic leukemia (ALL) is a highly aggressive neoplasm of hematopoietic cells of lymphoid lineage….

Head and Neck Cancer Lori J. Wirth, Paul M. Busse, Daniel Deschler INTRODUCTION Cancers of the head and neck are composed of a spectrum of malignant neoplasms. Most commonly, however,…

Rectal Cancer Theodore S. Hong EPIDEMIOLOGY In 2013 there were approximately 143,000 Americans diagnosed with colon and rectal cancer. Approximately 2/3 will involve the colon and 1/3 the rectum. Epidemiological…