The Key to Rational Chemoprevention
Cell line Reported IC50 (μM) Concentration (in μg/mL) Citations Cervical HeLa 80 24.18 Priyadarsini et al. (2011) Breast MCF-7 92.4 27.93 Chou et al. (2010) Prostate PC-3 100 30.22 Senthilkumar…
ONCOLOGY
Factors May Influence the Clinical Outcome of Chemotherapy in Cancer Multidrug Resistance
Fig. 1 Mechanisms of MDR towards cancer chemotherapeutic drugs. Cancer cells can develop resistance to multiple drugs by various mechanisms as depicted. Mechanisms include (a) decreased uptake of drug, (b)…
Ketogenic Diet as an Adjuvant Therapy for Brain Tumors and Other Cancers
Fig. 1 The KD alters overall gene expression to more closely resemble that seen in normal brain. Total cellular RNA was isolated from the tumor and the non-tumor containing contralateral…
in the Development of Black Seed-Derived Anticancer Agents
Fig. 1 Figure shows a timeline of the various periods (over the last 3000–4000 years) of Black seed use that has led to the discovery of Thymoquinone. The first description…
Role of Chemokine Receptor Signaling Axis and Natural Bioactive Chemopreventive Agents in Metastasis of Breast Cancer
Fig. 1 Schematic overview of CXCR4-SDF-1α-induced intracellular signal transduction pathway and desensitization of activated receptor signaling Since SDF-1α is constitutively expressed, it has been reported that shutting off continuous stimulation…
Bacteria in Patients Treated with Chemotherapy and Radiation Therapy
Trial numbera Objectives Patient population Intervention Stage of trial Country NCT01473290 Prevention of gastrointestinal complication Cancer patients treated by chemotherapy or radiation therapy to pelvic region VSL#3 (mixture of probiotic…
Factors and Breast Cancer
Ahern TP, Pedersen L, Tarp M et al (2011) Statin prescriptions and breast cancer recurrence risk: a Danish nationwide prospective cohort study. J Natl Cancer Inst 103:1461–1468 Alexander DD, Morimoto…
Isoflavones in the Breast Cancer Risk: From Preclinical Findings to Clinical Strategy
Fig. 1 Molecular targets of genistein on cancer cells. Genistein exhibits either stimulatory or inhibitory effects on different signaling pathways. Abbreviations: COX-2 cyclooxygenase-2, FAK focal adhesion kinase, HIF-1α hypoxia-inducible factor…
Role of Energy Balance in Cancer Prevention
Ahmed RL, Schmitz KH, Anderson KE, Rosamond WD, Folsom AR (2006) The metabolic syndrome and risk of incident colorectal cancer. Cancer 107:28–36 Alberti KGMM, Zimmet P, Shaw J (2006) Metabolic…
Role of Dietary Polyphenols in Prostate Cancer Chemoprevention
Fig. 1 Polyphenolic phytochemicals in prevention of prostate cancer 2 Epigallocatechin-3-Gallate Epigallocatechin-3-gallate (EGCG) represents the major polyphenol constituent present in green tea, the most popular beverage next to water. The…
