Quality of Life in Patients with Ovarian Cancer
Fig. 14.1 Conceptual model of QOL in ovarian cancer (Adapted from Kornblith et al. [2] and [3]) As recognition of the importance of QOL as a patient-centered outcome has increased…
ONCOLOGY
Targeted Molecular Therapy for Patients with Ovarian Cancer
Fig. 12.1 Mediators of tumor angiogenesis Antiangiogenic Agents Bevacizumab Bevacizumab is a recombinant, humanized, monoclonal immunoglobulin G1 antibody targeted at VEGF-A, which is approved for the treatment of metastatic colorectal…
Ovarian Cancer in the Pediatric Population
Fig. 8.1 Distribution of tumor histopathology shown as a percentage of total ovarian tumors in SEER database study (From Brookfield et al. [4]; with permission) Table 8.1 Histologic classification of…
Ovarian Cancer Screening and Early Detection
Biomarker Description Method Reference CA 15-3 Tumor antigen Serum ELISA Woolas et al. [41] CA 19-9 Tumor antigen Serum ELISA Woolas et al. [41] TAG-72 Tumor antigen Serum ELISA Woolas…
Management of Patients with Early-Stage Ovarian Cancer
Professional group Recommendation US Preventive Services Task Force Does not recommend routine screening, concluding that “the potential harms outweigh the potential benefits” American Cancer Society Does not recommend routine screening;…
Psychological Aspects of Hereditary and Non-hereditary Ovarian Cancer
Level of evidence Factor Most frequently observed observation Strong Age Younger age—more distress Disease stage More advanced disease—more distress Time since diagnosis Shorter—more distress Disability status Worse—more distress Physical symptoms…
Management of Hereditary Ovarian–Breast Cancer
Established risk factors Possible risk factors Suspected risk factors Age Early age at menarche Hormonal replacement therapy Family history – genetics Late age at menopause Dietary fat Nulliparity Infertility Obesity…
Genetic Risks of Ovarian Cancer
Syndrome Manifestations Inheritance Gene(s) Reference Hereditary breast and ovarian cancer Early-onset breast or ovarian cancer, multiple primary cancers, cancer in several generations, male breast cancer AD BRCA1 [19] BRCA2 [20]…
Strategies for the Management of Ovarian Cancer
9. Eisenhauer EL, Abu-Rustum NR, Sonoda Y, Levine DA, Poynor EA, Aghajanian C, et al. The addition of extensive upper abdominal surgery to achieve optimal cytoreduction improves survival in patients…
Epidemiology of Ovarian Cancer: An Update
Fig. 1.1 Worldwide ovarian cancer incidence and mortality rates. Rates are per 100,000 and represent age-standardized rates according to the world standard population (ASR (W)) (From the International Agency for…
