Fig. 21.1 Tumor incidence in two models of HCC and EtOH consumption. (a) Twenty-one-day-old male C57BL/6 or B6C3 mice were injected with vehicle (Veh; 100 μL sterile olive oil) or…
Fig. 17.1 CEA processing and metastatic potential of colorectal cancer cells (CRC) in the alcohol-injured liver. (a) The potential effects of alcohol on the direct processing of CEA by Kupffer…
Fig. 5.1 The reaction of acetaldehyde with deoxyguanosine results in the formation of N2-ethylidendene-dG; this unstable Schiff base can be converted through a reduction step to the more stable form:…
Reference Gender Age FASD Cancer type [7] M 28 months Yes Neuroblastoma [11] F 3 years 9 months Yes, with hydantoin Hodgkin disease [33] F 12years 11 months Yes Adrenal…
Group Tumor foci Adenoma % Incidence Multiplicity % Incidence Multiplicity Chow + DEN (n = 17) 16/17 = 94 100/17 = 5.8a 1/17 = 6 2/17 = 0.1a PF + DEN (n = 18) 18/18 = 100* 209/18 = 11.6b 10/18 = 55* 15/18 = 0.8b EtOH + DEN (n = 15) 16/15 = 100* 266/15 = 17.7c 9/15 = 60* 33/15 = 2.2c % Incidence = number…
Fig. 20.1 Hematopoiesis. The current model of hematopoiesis is depicted below. In this model hematopoietic cells are derived from a small number of HSCs that progress through a series of…
Fig. 16.1 ALDHs modulate carcinogenesis by metabolizing acetaldehyde and retinaldehyde. Ethanol is metabolized by alcohol dehydrogenase (ADH), catalase, and CYP2E1 to acetaldehyde. Acetaldehyde can interfere with antioxidative defense systems (AODS)…
Fig. 15.1 Phenotypes of the alcohol dehydrogenase-1B*1/*1 (ADH1B*1/*1) and aldehyde dehydrogenase-2*1/*2 (ALDH2*1/*2) genotypes and their relationships to ethanol and acetaldehyde exposure and accumulation 15.3 ALDH2 Genotype and Squamous Cell Neoplasia…
Fig. 8.1 Synergistically increased risk for HCV-mediated HCC by alcohol abuse or/and obesity. Comorbidity such as alcohol abuse and obesity synergistically heightens the risk of developing HCC by 6- to…
Fig. 10.1 Schematic model showing the overall domain structure and posttranslational modifications of PTEN. PTEN is a 403 amino acid protein that contains five domains. On the N-terminal side is…
