Fig. 19.1 G protein-coupled receptor (GPCR) that is coupled to a Gq heterotrimeric G protein, on binding with the ligand induce activity in the PLC (phospholipase C) isozyme PLC-β, which…
Fig. 18.1 Schematic representation of targets of telomerase and telomere structure for various anticancer strategies Table 18.1 Telomere- and telomerase-associated proteins and their inhibitors Target Approach Mechanism and consequence Examples…
Fig. 13.1 Gastrointestinal cancers in different parts of India Salient features of the review: Esophageal cancer is highest in northeastern region of India than other parts of the world for…
© Springer International Publishing Switzerland 2015Varsha Gandhi, Kapil Mehta, Rajesh Grover, Sen Pathak and Bharat B. Aggarwal (eds.)Multi-Targeted Approach to Treatment of Cancer10.1007/978-3-319-12253-3_11 11. Gall Bladder Cancer: What Needs to Be Done in India? Vinay K. Kapoor1 (1) Sanjay Gandhi…
© Springer International Publishing Switzerland 2015Varsha Gandhi, Kapil Mehta, Rajesh Grover, Sen Pathak and Bharat B. Aggarwal (eds.)Multi-Targeted Approach to Treatment of Cancer10.1007/978-3-319-12253-3_3 3. Chronic Lymphocytic Leukemia at the Genomic Level Hima V. Vangapandu1, 2 and Varsha Gandhi1, 2, 3 (1)…
Fig. 5.1 TAM in modulating cancer-related inflammation. TAM participate in many aspects of cancer growth and progression. More in details, they sustain tumor growth through the release of growth factors,…
Fig. 9.1 (a) Feedback loops of the PI3K/Akt/mTOR pathway. Red line means inhibition and black activation; in blue: PI3k/Akt/mTOR pathway; in brown: MAPK pathway. (b) Two ways of blocking the…
Fig. 8.1 Chemical structures of sirolimus (a), temsirolimus (b), everolimus (c), and ridaforolimus (d) [4] Rapalogs retain the basic structure of the parent rapamycin compound, but differ by the moiety…
Fig. 12.1 The PI3K pathway and associated inhibitor classes. Schematic representation of the PI3K/Akt/mTOR pathway (red) and the MAPK pathway (blue) including recognized points of crosstalk between the respective cascades….
Fig. 10.1 Oncogenic activation of mTOR may be related to multiple oncogenic activations, mutations of major anti-oncogenes as well as microenvironment-dependent parameters such as hypoxia and nutrient depletion Knowing how…
