Allergies and Cancers
Fig. 21.1 Type I allergic reaction. B B cell, DC dendritic cell, eo eosinophilic granulocyte, IgE immune globulin E, IL interleukin, MC mast cell, Th2 T helper cell type 2,…
ONCOLOGY
Immunosenescence, Oxidative Stress, and Cancers
7. Miki C, Kusunoki M, Inoue Y, et al. Remodeling of the immunoinflammatory network system in elderly cancer patients: implications of inflamm-aging and tumor-specific hyperinflammation. Surg Today. 2008;38:873–8.PubMed 8. Vasto…
Role of Plasmacytoid Dendritic Cells in Cancer
Marker Structure/function Ligand Effect of activation BDCA-2/BDCA-4 Associated with FcεRlγ to form a signaling receptor complex ITAM Upon ligation, they inhibit TLR activation and release of type I IFN CD4…
Primary Immunodeficiencies and Cancers
Gene Disease Inheritance Clinical features Pathogenesis Immune defects Associated cancers ATM (OMIM*607585) Ataxia-telangiectasia AR Cerebellar ataxia, oculocutaneous telangiectasia, chromosomal instability, radiosensitivity, thymic aplasia, recurrent sinopulmonary infections, cancer predisposition (up 40…
Autophagy and Necroptosis in Cancer
Fig. 14.1 Autophagy signaling pathway and antitumor therapeutic targets 14.2 Autophagy and Cancer The role of autophagy in cancer is rather perplexing. It is widely postulated that the autophagic pathway…
Role of Cytokines in Tumor Immunity and Immune Tolerance to Cancer
Fig. 7.1 IL-12 links innate and adaptive antitumor immunity. IL-12 utilizes several mechanisms to induce antitumor effects. IL-27 activates innate effectors, such as NK cells, NKT cells, and γδ −…
Epigenetics and microRNAs in Cancer
© Springer-Verlag Berlin Heidelberg 2015Nima Rezaei (ed.)Cancer Immunology10.1007/978-3-662-44006-3_16 16. Epigenetics and microRNAs in Cancer Petra M. Wise1, 2 , Kishore B. Challagundla1, 2 and Muller Fabbri1, 3 (1) Department of Pediatric Hematology/Oncology, Children’s Center for Cancer and Blood Diseases, Norris…
Prognostic Value of Innate and Adaptive Immunity in Cancers
50. Allavena P, Sica A, Garlanda C, Mantovani A. The yin-yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev. 2008;222:155–61.PubMed 51. Bottazzi B, Polentarutti N, Acero R,…
Role of Innate Immunity in Cancers and Antitumor Response
Fig. 3.1 Role of innate immune receptors in the regulation of antitumor immunity. (a) The functions of the innate immune system are regulated by various receptors expressed in immune cells….
Regulatory T Cells and Th17 Cells in Cancer Microenvironment
Fig. 6.1 Potential roles of FoxP3+ T cells and Th17 cells in tumors. (a) FoxP3+ T cells are made in the thymus as naïve-type FoxP3+ T cells, which migrate to…
