Phenotype Molecular basis Mechanism Consequence AR-addicted Adrenal or intra-tumoral androgen biosynthesis Androgens produced sufficient to activate AR Responds to androgen biosynthesis inhibitors and selected AR antagonists AR mutation Alters ligand…
Fig. 5.1 Schematic of the full-length androgen receptor and exon structure of major splice variants (ARV7 (b) and ARV567 (c)). Domains of AR include the amino (N) terminal domain, the…
Fig. 10.1 The vicious cycle of bone metastases Transforming growth factor beta (TGFβ) is released from resorbed bone matrix and has been shown to augment signaling through parathyroid hormone-related protein…
Target Agent(s) Phase Summary Identifier mTOR Everolimus (Docetaxel) (Bevacizumab) Ib/II Dose-finding/efficacy study; Docetaxel + everolimus + bevacizumab in metastatic CRPC NCT00574769 mTOR Temsirolimus (Bevacizumab) I/II Dose-finding/efficacy study; Temsirolimus + bevacizumab in metastatic CRPC NCT01083368 mTOR Everolimus…
Question 7.1 The family depicted has Lynch syndrome (previously referred to as the hereditary nonpolyposis colon cancer [HNPCC]) syndrome. This syndrome is characterized by a high risk to develop colon…
!DOCTYPE html PUBLIC “-//W3C//DTD XHTML 1.1//EN” “http://www.w3.org/TR/xhtml11/DTD/xhtml11.dtd”> 34 Oncologic Emergencies Preet Paul Singh QUESTIONS Each of the numbered items below is followed by lettered answers. Select the ONE lettered answer…
!DOCTYPE html PUBLIC “-//W3C//DTD XHTML 1.1//EN” “http://www.w3.org/TR/xhtml11/DTD/xhtml11.dtd”> 33 Stem Cell Transplantation Brian Hess and Rizwan Romee QUESTIONS Each of the numbered items below is followed by lettered answers. Select the…
!DOCTYPE html PUBLIC “-//W3C//DTD XHTML 1.1//EN” “http://www.w3.org/TR/xhtml11/DTD/xhtml11.dtd”> 31 Plasma Cell Neoplasms Ravi Vij and Jesse Keller QUESTIONS Each of the numbered items below is followed by lettered answers. Select the…
!DOCTYPE html PUBLIC “-//W3C//DTD XHTML 1.1//EN” “http://www.w3.org/TR/xhtml11/DTD/xhtml11.dtd”> 32 Immunosuppression-Related Malignancies Lee Ratner QUESTIONS Each of the numbered items below is followed by lettered answers. Select the ONE lettered answer that…
One of the most prognostically significant landmarks is achieving CCyR at 12 months and many other parameters are based on the likelihood of obtaining this response. For example, for patients…
