4 Genetic Screening Cheryl J. Pendergrass KEY POINTS • Genetic testing is an important part of the clinical care of patients with colorectal cancer. • Prior to genetic testing, patients…

17 Surveillance and Follow-up Matthew T. Hueman, Nita Ahuja KEY POINTS • The majority of colorectal recurrences occur within the first 2 to 3 years after diagnosis, and 90% occur…

10 Radiologic Techniques: Virtual Colonoscopy Karen M. Horton KEY POINTS • Virtual colonoscopy is an innovative application for computed tomography (CT) in which CT data and specialized three-dimensional (3D) software…

20 Genetic Profiling in Colorectal Cancer Debashish Bose, Nita Ahuja KEY POINTS • Genetic profiling is the attempt to classify disease states by the molecular characteristics of tumor tissue or…

15 Systemic Therapy for Colon Cancer Khaled El-Shami, Sujatha Nallapareddy, Wells Messersmith KEY POINTS • Systemic therapy for colorectal cancer is rapidly changing, with six new drugs introduced during the…

19 Vaccines and Immunotherapy Ajay Jain, Richard Schulick KEY POINTS • Immunotherapy is a therapeutic strategy in which a patient’s immune responses are modulated to eradicate malignant cancer cells. •…

6 Chemoprevention of Colorectal Cancer Melissa A. Munsell, Francis M. Giardiello KEY POINTS • The chemopreventive effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is supported by in vitro experiments, animal models,…

12 Limited Resection: Indications, Techniques, and Outcomes of Transanal Excision and Transanal Endoscopic Microsurgery Elizabeth C. Wick KEY POINTS • Local excision is applicable in a select subset with early…

13 Endoscopic Techniques in Colorectal Neoplasia Eun Ji Shin, Samuel A. Giday KEY POINTS • Endoscopic techniques that are discussed include endoscopic resection and colonic stenting. • Endoscopic resections are…

9 Stool and Blood Sampling for Early Detection of Colorectal Cancer Jason K. Sicklick, Nita Ahuja KEY POINTS • Screening methods have been applied for the detection of premalignant colonic…