Strategies in Mantle Cell Lymphoma
Fig. 1 Our approach to MCL treatment Table 1 Frontline regimens in patients ≤70 years Frontline regimen Age (years) ORR (%) PFS/FFS OS R-Hyper-CVAD [16] ≤81 97 3 years 64 % (≤65 3 years 73 %)…
ONCOLOGY
of B-Cell Lymphomas: Diagnosis and Biomarker Discovery
Expected immunophenotype Follicular lymphoma CD19+, CD20+, IgM ± IgD, monotypic sIg+, CD10+, bcl-6+, bcl-2 ±, HGAL, LMO2; associated with CD21+/CD23+ follicular dendritic cell meshworks Lymphoplasmacytic lymphoma CD19+, CD20+, monotypic sIg+, IgM, CD22+,…
Immunoglobulins and Laboratory Recognition of Monoclonal Proteins
IgG IgA IgM IgD IgE Heavy chain Classes Gamma (γ) Alpha (α) Mu (μ) Delta (δ) Epsilon (ε) Subclasses IgG1, IgG2, IgG3, IgG4 IgA1, IgA2 None None None Light…
Histopathology, Morphology and Immunophenotyping of CLL
Fig. 7.1 Peripheral blood film showing typical CLL cells and a smear cell (1,000× magnification) Fig. 7.2 Peripheral blood film showing prolymphocytes along with typical CLL cells (1,000× magnification) In…
Classification of the Acute Leukemias: Cytochemical and Morphologic Considerations
Fig. 16.1 ALL: PAS reaction. Note the block-like reaction product Fig. 16.2 AML (FABM0). Blasts with no differentiation. Peroxidase negative but with positive myeloid antigens by flow cytometry Fig. 16.3…
Heavy-Chain Disease
Feature Type of heavy-chain disease α γ μ Year described 1968 1964 1969 Incidence Rare Very rare Very rare Age at diagnosis Young adult (<30 years) Older adult (60–70 years)…
Pathology of Non-Hodgkin’s and Hodgkin’s Lymphomas
Low grade A. Malignant lymphoma, small lymphocytic Consistent with chronic lymphocytic leukemia Plasmacytoid B. Malignant lymphoma, follicular, predominantly small cleaved cell Diffuse areas Sclerosis C. Malignant lymphoma, follicular, mixed small…
Pathology of the Chronic Myeloid Leukemias
Fig. 3.1 Peripheral blood (PB) film from a patient with chronic myelogenous leukemia with an unusually high white cell count showing an increase of neutrophils, eosinophils, basophils, and granulocyte precursors….
Diagnosis and Therapy of Immunoglobulin Light Chain Amyloidosis (AL Amyloidosis)
Fig. 37.1 An enlarged tongue in a patient with AL amyloidosis Fig. 37.2 Clinical presentation of classic vascular purpura The Congo Red Stain The only accepted diagnostic test to validate…
The Etiology of Acute Leukemia
Fig. 14.1 The two-hit model of acute leukemogenesis. This model hypothesizes that AML and ALL are the consequence of a combination of at least two broad classes of mutations. Class…
