Symptoms Pain Fatigue Nausea Appetite Discomfort Dyspnea Sleep disturbance Depression Anxiety Existential/psychic pain Health care related ICU stay Chemotherapy at the end of life Hospital death Use of feeding tubes…
Fig. 2.1 Europe, 2012, head and neck cancers incidence. H&N = lip, tongue, oral cavity, pharynx, larynx, salivary glands, nasopharynx and nasal cavities (GLOBOCAN 2012 (IARC) – 2.11.2015) Fig. 2.2…
Fig. 1.1 ‘About Face I’ survey responses to question, “Are you familiar with the term head and neck cancer?” Although the majority of respondents recognised that HNC affects the pharynx…
Study/author/year No. patients Sites/no. pts. OP/OC/HP/L Stage (UICC) Fractionation schedule OTT (weeks) Total dose in tt.-arms LC/LRC (%) PFS (%) OS (%) Acute toxicities Late morbidities Pinto et al. (1991)…
Fig. 7.1 (a) Endoscopic view of a squamous cell carcinoma (SCC) of the left vocal fold. (b) Preoperative CT scan of the same lesion showing the invasion of the left…
Figs. 8.1 and 8.2 A superior aesthetic result from an implant-supported prosthesis rivalling any potential result achievable with autogenous tissue transfer Head and neck patients offer a unique set of…
Fig. 3.1 Growth factor independence leads to sustained signalling in pathways that control essential biological functions. Binding of ligand to the extracellular ligand-binding domain leads to receptor dimerisation and activation…
Author No. of Pts Treatment Response rate (%) Median survival (months) First–line treatment chemotherapeutic agents Jacobs 245 PF P F 32a 17 13 5.5 5.0 6.1 Forastiere 277 PF CF…
Regimens N ORR (%) Median survival (months) Reference Cisplatin/5-FU 249 32 % 5.5 months [26] vs. Cisplatin 17 % 5 months vs. 5-FU 13 % 6.1 months Cisplatin/methotrexate/bleomycin/vincristine…
Tracer First author, year Type Target/process 18F-FMISO Rajendran, 2006 [14] Nitroimidazole Hypoxia 18F-FAZA Mortensen, 2012 [15] Nitroimidazole Hypoxia 18F-HX4 Zegers, 2015 [16] Nitroimidazole Hypoxia 18F-EF5 Komar, 2014 [17] Nitroimidazole Hypoxia…
