Nelarabine
Fig. 14.1 The chemical structures of nelarabine and ara-G. (a) Nelarabine. (b) Ara-G 14.2 Mechanisms of Action 14.2.1 Mechanisms of Action (Fig. 14.2) In the blood, nelarabine is rapidly demethoxylated…
ONCOLOGY
Blinatumomab for Acute Lymphoblastic Leukemia: Clinical Pharmacology and Therapeutic Results
Fig. 8.1 Blinatumomab has anti-CD19 single-chain Fv (scFv) fragment at N-terminal and anti-CD3 scFv fragment at C-terminal. Each scFv is composed of V light chain and V heavy chain. Each…
Therapies Targeting Leukemic Stem Cells
Fig. 20.1 Various causes of LSC development In recent years, new techniques have begun to revolutionize the diagnosis, prognosis, and classification of leukemia. More recently, the introduction of high-speed analysis…
Epigenetic Regulator, Re-emerging Antimetabolites with Novel Mechanism of Action (Azacitidine and Decitabine): Clinical Pharmacology and Therapeutic Results
Aza C Supportive care Crossover No. of patients % No. of patients % No. of patients % No. evaluated 99 92 49 CR 7 7* 0 0 5 10…
Clinical Use of Clofarabine for Adults and Children with Leukemia
Reference Regimen Patients (no.) Median age (years) ORR (%) CR (%) OS Kantarjian et al. [19] Clofarabine monotherapy 112 71 46 38 41 weeks Faderl et al. [26]a Clofarabine +…
The Molecular Basis of Arsenic Trioxide Treatment for Acute Promyelocytic Leukemia (APL)
Fig. 12.1 The molecular mechanism of action of ATO in APL. ATO binds to the B2 domain of the PML moiety of the PML-RARĪ± protein, inducing binding of UBC9 followed…
Inotuzumab Ozogamicin for Acute Lymphoblastic Leukemia: Clinical Pharmacology and Therapeutic Results
Author Year IO Dose No. of patients Response (%) Advani A 2010 Single 1.8 mg/m2 FL: 22 FL: 68 DLBCL:26 DLBCL: 15 Ogura M 2010 Single 1.8 mg/m2 FL: 10…
Rituximab and Alemtuzumab for Chronic Lymphocytic Leukemia: Clinical Pharmacology and Therapeutic Results
Fig. 6.1 Treatment strategy of B-CLL by the GCLLSG. Abbreviations: FCR fludarabine, cyclophosphamide, and rituximab, BR bendamustine and rituximab, R-idelalisib rituximab and idelalisib, SCT stem cell transplantation, G-CLB obinutuzumab and…
Bcr-Abl Tyrosine Kinase Inhibitors (TKIs)
Related posts: Inotuzumab Ozogamicin for Acute Lymphoblastic Leukemia: Clinical Pharmacology and Therapeutic Results Clinical Use of Clofarabine for Adults and Children with Leukemia Nelarabine Rituximab and Alemtuzumab for Chronic Lymphocytic…
Dying: What Happens in the Cells and Tissues
Fig. 2.1 Morphology of cell deaths (Grasso et al. 2012) The molecular and genetic basis of apoptosis has been extensively explored. Defining programmed cell death by biochemical processes rather than…
