Fig. 17.1 Size distribution of maximal tumor diameter in 4138 adult PTC patients consecutively treated at Mayo during 1935–2014 and demonstrating that one-third of these patients during the eight decades…
Surveillance method Description Advantages/benefits Disadvantages/limitations Thyroglobulin (Tg) Protein product of thyroid follicular cells Most sensitive method for detecting the presence of disease, particularly after stimulation with rhTSH or THW Wide…
External Beam Radiotherapy External beam radiotherapy is a useful option in advanced DTC, particularly when the disease is iodine nonavid. It is most commonly used to treat surgically unresectable locoregional…
Implied risk of malignancy according to TBSRTC (%) [1] Estimated risk based on reported studies (%) [5] Atypia of unknown significance/follicular lesion of unknown significance (AUS/FLUS) 5–15% 6–48% Follicular…
Fig. 14.1 Anatomical boundaries of the central neck compartment Within the central compartment, there are several groups of lymph nodes that are resected during a central compartment dissection. The prelaryngeal…
Fig. 1.1 Incidence by histology of thyroid cancer and mortality of thyroid cancer, 1975–2011. Data are from the Surveillance, Epidemiology, and End Results (SEER) program (www.seer.cancer.gov) SEER*Stat Database: Incidence—SEER 9…
Year Diseasea Study size Age Size Extent/T-stage Lymphnode status Metastases Gender Grade Histology Others No. of riskgroups EORTC 1979 PTC, FTC,MTC, ATC 507 X X X X X 5…
Arguments for elective neck surgery Arguments against elective neck surgery Improved staging Extremely low rates of recurrence if observed Improved targeting of adjuvant therapy Excellent survival without elective surgery Reduced…
Tumor Genes Frequency Citations PTC BRAF 40–50% [2, 4–8] RET/PTC 10–20% [2, 9, 10] RAS 10–20% [11–15] TRK 5–13% [16] TERT 9% [2] EIF1AX 2% [2] FTC RAS 20–50% [13,…
© The Author(s) 2017Anne T. Mancino and Lawrence T. Kim (eds.)Management of Differentiated Thyroid Cancer10.1007/978-3-319-54493-9_6 6. Clinical Presentation and Diagnosis of Papillary Thyroid Cancer Cord Sturgeon1 , Dina Elaraj1 and Anthony Yang1 (1) Department of Surgery, Section of Endocrine…
