An Update on Randomized Clinical Trials in Melanoma
Despite many advances in the treatment of melanoma, it still continues to be a disease that affects many people. Fortunately, there have been a multitude of randomized trials that have…
ONCOLOGY
The Evolution of Oncology Clinical Research: Lessons Learned
The purpose of clinical research is to add to medical knowledge using hypothesis-driven scientific methods for the betterment of clinical care and for ultimate improvement in patient outcomes. Over the…
Clinical Trials in Surgical Oncology
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA www.surgonc.theclinics.com Consulting Editor NICHOLAS J. PETRELLI October 2017 • Volume 26 • Number 4 Related posts: The Evolution of Oncology Clinical Research: Lessons Learned…
Molecular Biology of Leukemias
Chromosomal translocations Genes Comments Involving RARAα t(15;17)(q21;q21) PML DNA binding, cell proliferation RARα Transcription factor t(11;17)(q23;q21) ZBTB16 (PLZF) Zn-finger transcription factor RARα Transcription factor t(5;17)(q32;q21) NPM1 RNA transport/processing RARα Transcription…
Molecular Mechanisms in Non-Hodgkin Lymphoma
(1) Department of Patholog, University of Massachusetts Medical School, Baystate, Springfield, MA, USA (2) Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC,…
Cancer Epidemiology: Incidence and Etiology of Human Neoplasms
Fig. 1.1 Cancer incidence and mortality by site for both sexes (USA, 2015). The relative contributions of the major forms of cancer to overall cancer incidence and cancer-related mortality (both…
Small Molecule Inhibitors
Fig. 40.1 Discovery of imatinib . Binding of imatinib occurs at the ATP-binding site as indicated by docking studies [28] and X-ray crystallography [29]. It has also been shown from…
Essential Concepts and Techniques in Molecular Biology
Fig. 2.1 Chemical structures of DNA and RNA. The DNA within the eukaryotic nucleus is arranged in a double-stranded helix composed of two strands of opposing polarity. The helix is…
Simple Sequence Mutations
Fig. 13.1 Genetic heterogeneity of cancer cells. All cancer cells are derived from a common ancestor cell (black dot) that was subject to the pathogenic mutation (w). After an initial…
Molecular Biology of Human Brain Tumors
Fig. 35.1 MRI sequences of common primary brain tumors. (a) Sagittal T1-weighted and gadolinium-enhanced MR image showing a medulloblastoma in the posterior fossa (arrow) with compression of the pons and…
