Date approved Drug Place Disease May 2003 Bortezomib USA (FDA) Multiple myeloma December 2003 Thalidomide Australia Multiple myeloma February 2004 Bevacizumaba USA (FDA) Colorectal cancer November 2004 Erlotinib USA (FDA)…
© Springer Science+Business Media New York 2017William B. Coleman and Gregory J. Tsongalis (eds.)The Molecular Basis of Human Cancer10.1007/978-1-59745-458-2_29 29. Molecular Basis of Skin Carcinogenesis Alessia Pacifico1 , Giovanni Leone1 and Honnavara N. Ananthaswamy2 (1) Phototherapy Unit, S. Gallicano Dermatological…
SCLC NSCLC Frequency ~20–25 % ~75–80 % Histology Scant cytoplasm, small hyperchromatic nuclei, fine chromatin, indistinct nucleoli, tumor in sheets Abundant cytoplasm, pleomorphic nuclei, coarse chromatin, prominent nucleoli, squamous/glandular…
© Springer Science+Business Media New York 2017William B. Coleman and Gregory J. Tsongalis (eds.)The Molecular Basis of Human Cancer10.1007/978-1-59745-458-2_27 27. The Molecular Basis of Prostate Carcinogenesis Smitha Dutt1 and Allen C. Gao1 (1) Department of Urology and Cancer…
Risk factor Relative risk (RR) Family history First-degree relative with BC 2.40 Mother with BC before the age of 50 2.41 Sister with BC before the age of 50 3.18…
Fig. 21.1 Clinical outcomes of HPV vaccination trials in an intention-to-treat meta-analysis. Adapted from [35]. Another form of cancer with an infectious etiology is gastric cancer. Helicobacter pylori (H. pylori)…
© Springer Science+Business Media New York 2017William B. Coleman and Gregory J. Tsongalis (eds.)The Molecular Basis of Human Cancer10.1007/978-1-59745-458-2_19 19. Viral Mechanisms in Human Carcinogenesis Paul F. Lambert1 (1) McArdle Laboratory for Cancer Research, Department of Oncology,…
Tumor type miRNAs Comments Reference(s) Brain, GBM miR-21, miR-221, miR-222, (up) miR-21 upregulated in all high-grade tumors [45, 47] Breast cancer miR-21, miR-155b (up) miR-125b, miR-145 (down) Expression levels correlate…
© Springer Science+Business Media New York 2017William B. Coleman and Gregory J. Tsongalis (eds.)The Molecular Basis of Human Cancer10.1007/978-1-59745-458-2_11 11. Novel Cancer Therapies Targeting Angiogenesis Monte S. Willis1 and Nancy Klauber-DeMore2 (1) Department of Pathology and Laboratory Medicine,…
Fig. 8.1 Critical signaling pathways as drug targets for cancer therapy. (a) Surface receptors dimerize and activate downstream effectors such as RAS (a GTPase). Many surface receptors are targeted by…
