Epidemiology of Anal Canal Cancer
Anal cancer is a rare malignancy, although its incidence has been increasingly in recent decades. This article discusses risk factors for anal cancer and how these risk factors affect the…
ONCOLOGY
Patient Perspective and Personal Journey of Treating a “Rare Cancer”
I was diagnosed with rare anal cancer. As overwhelming as the diagnosis was, it was complicated by limited treatment infrastructure and clinical research, side-effect management, and lack of awareness and…
Issues in the Management of Esophagogastric Cancer in Geriatric Patients
Esophagogastric cancers predominantly affect older adults; however, older patients are less likely to be recommended for both curative and palliative treatment. Older patients have unique challenges that need to be…
Nutritional Support in Esophagogastric Cancers
Esophageal and gastric cancers are common malignancies, both in the United States and worldwide, that carry significant morbidity and mortality. Malnutrition is a common complication in patients with esophageal and…
Current Progress in Human Epidermal Growth Factor Receptor 2 Targeted Therapies in Esophagogastric Cancer
Esophagogastric cancer is a worldwide health problem. The addition of the epidermal growth factor receptor 2 (HER2)-directed antibody trastuzumab to chemotherapy increased the overall survival of patients with metastatic HER2-positive…
Novel Targeted Therapies for Esophagogastric Cancer
Gastroesophageal cancer (GEC) remains a major cause of cancer-related mortality worldwide. Although the incidence of distal gastric adenocarcinoma (GC) is declining in the United States, proximal esophagogastric junction adenocarcinoma (EGJ)…
The Current Status of Immunotherapies in Esophagogastric Cancer
This review summarizes completed and ongoing studies evaluating the activity of immune checkpoint inhibitors in esophagogastric cancer. Key points • Immune checkpoint inhibitors that target cytotoxic T lymphocyte antigen-4 or…
Radiation Therapy for Locally Advanced Esophageal Cancer
The treatment of locally advanced esophageal cancer is controversial. For patients who are candidates for surgical resection, multiple prospective clinical trials have demonstrated the advantages of neoadjuvant chemoradiation. For patients…
Controversies and Consensus in Preoperative Therapy of Esophageal and Gastroesophageal Junction Cancers
This review summarizes established adjuvant approaches for locally advanced esophageal cancer (including preoperative, perioperative, or postoperative approaches, which include chemotherapy alone or chemoradiation). It also discusses areas of uncertainty and…
The Asian Perspective on the Surgical and Adjuvant Management of Esophagogastric Cancer
In East Asia, D2 dissection has been routine surgical procedure for curable advanced gastric cancer. More extended surgery than D2 is reserved for borderline resectable disease with extended nodal metastasis….
