Introduction Over the last several years, molecularly targeted therapy has emerged as a new generation of cancer treatment and has been integrated into treatment protocols of many hematologic and solid…
Introduction Cancer treatments have the potential to cause infusion reactions (IRs). It is important to manage IRs because they may cause treatment disruption and require costly medical interventions. Both cytotoxic…
Introduction Cardiotoxic effects of chemotherapy are challenging in nature, since myocardial tissue possesses limited regenerative capacity, which renders the heart susceptible to transient and permanent side effects of chemotherapy agents….
Introduction Chemotherapy can affect skin in various ways, and several chemotherapeutic agents have been linked to distinctive cutaneous side effects. Although these side effects are rarely life-threatening, they can cause…
Mechanisms of Cancer-Directed Therapies Cancer has been prevalent for centuries and humans have been concerned with the treatment of cancer for a seemingly equal time. Breast cancer was first described…
Introduction Respiratory insufficiency in patients receiving systemic chemotherapy often is a diagnostic dilemma for clinicians. Patients receiving chemotherapy are frequently immunosuppressed and may have concurrent bone marrow suppression, or pulmonary…
Introduction Chemotherapy-related neurotoxicity is a frequently observed side effect that has become more prevalent with the increasing number of long-term cancer survivors. These toxicities can be peripheral or central and…
Introduction Gastrointestinal (GI) toxicities are common side effects of most chemotherapy agents. Their effect on rapidly dividing GI tract cells can lead to mucosal inflammation, ulceration, and perforation. The most…
Introduction ■ Mucositis is defined as inflammation of the mucous membranes lining the alimentary tract, causing mucosal injury. Mucositis can occur in response to systemic chemotherapy or other etiologies (e.g.,…
Introduction ■ A multitude of cancer treatments are known to cause thrombocytopenia (TCP), termed treatment-related thrombocytopenia. Chemotherapy-induced thrombocytopenia (CIT) is a term that refers specifically to thrombocytopenia caused by chemotherapy…
