Tyrosine kinase (TK) cascades are involved in all stages of tumorigenesis through modulation of transformation and differentiation, cell-cycle progression, and motility. Advances in molecular targeted drug development allow the design…
The elucidation of the heat shock response (HSR) as a mediator of cellular stress has created a framework for understanding how these processes may promote tumorigenesis. Furthermore, the identification of…
This article presents an overview of the PI3K/Akt/mTOR signaling pathway. As a central regulator of cell growth, protein translation, survival, and metabolism, activation of this signaling pathway contributes to the…
The role of the microenvironment during the initiation and progression of malignancy is appreciated to be of critical importance for improved molecular diagnostics and therapeutics. The tumor microenvironment is the…
William G. Cance, MD, Editor Over the last 20 years, we have gained a massive amount of knowledge about the genetic basis of human cancer. Culminating with the sequencing of…
At initial presentation, 20% to 30% of patients with colon and rectal cancer have detectable metastatic disease. Precise guidelines are lacking for the treatment of this special subset. Most of…
Functional outcomes of colorectal cancer treatment are an increasingly prominent interest of patients, clinicians, and researchers. The current literature on function after colorectal cancer treatment is difficult to assimilate, with…
There are an increasing number of reports on nonoperative management of rectal cancer patients who achieve a dramatic response to neoadjuvant therapy. This review discusses the current literature, and describes…
Abdominoperineal excision (APE) is a necessary operation in many patients with low rectal cancer. Outcomes after this procedure, however, have been variable and often suboptimal. With a new concept of…
Total mesorectal excision with preoperative radiation and chemotherapy provide the lowest local recurrence rates for rectal cancer. Timing of surgery after preoperative chemoradiation is being increased to optimize tumor downstaging….
