Breast Cancer Disparities
African American women have a lower lifetime incidence of breast cancer than white/Caucasian Americans yet have a higher risk of breast cancer mortality. African American women are also more likely…
ONCOLOGY
Nipple-Sparing Mastectomy
The guiding principles of nipple-sparing mastectomy (complete removal of the breast from its skin and reconstructing without changing the appearance of the breast) are based on patient safety followed by…
Basal-Like and Triple-Negative Breast Cancers
Triple-negative breast cancers (TNBC) are defined by their failure to express the estrogen receptor, progesterone receptor, and HER2/ neu protein markers. This basic feature is clinically relevant because it indicates…
Advances in Breast Reconstruction of Mastectomy and Lumpectomy Defects
Breast reconstruction continues to evolve along with advances in the detection and management of breast cancer. With more patients diagnosed with breast cancer earlier in life and increased identification of…
Neoadjuvant Therapy in the Treatment of Breast Cancer
Neoadjuvant systemic therapy in breast cancer treatment was initially utilized for inoperable disease. However, several randomized prospective studies have demonstrated comparable survival with adjuvant chemotherapy in early-stage, operable breast cancer…
Lobular Neoplasia
Lobular neoplasia (LN) is characterized by a dysfunctional E-cadherin-catenin axis, and loss of E-cadherin plays a causative role in the typical morphology of LN cells. LN is both a nonobligate…
Management of Axillary Disease
The presence of nodal metastases is the most important prognostic indicator in breast cancer, making accurate assessment of the axillary nodal basin critical to delivering optimal therapy in breast cancer….
Management of the Clinically Node-Negative Axilla in Primary and Locally Recurrent Breast Cancer
For patients with primary breast cancer, nodal status remains a key determinant for overall prognosis. Sentinel lymph node biopsy (SLNB) has become standard care for staging patients who have clinically…
Molecular Profiling of Breast Cancer
Breast cancer is now considered a heterogeneous and phenotypically diverse disease. Molecular profiling is used in clinical practice in 2 broad categories: (1) characterization of breast cancers beyond the standard…
Applications for Breast Magnetic Resonance Imaging
This article reviews the relevant data on breast magnetic resonance imaging (MRI) use in screening, the short-term surgical outcomes and long-term cancer outcomes associated with the use of MRI in…
