This article presents an overview of the PI3K/Akt/mTOR signaling pathway. As a central regulator of cell growth, protein translation, survival, and metabolism, activation of this signaling pathway contributes to the…
The role of the microenvironment during the initiation and progression of malignancy is appreciated to be of critical importance for improved molecular diagnostics and therapeutics. The tumor microenvironment is the…
William G. Cance, MD, Editor Over the last 20 years, we have gained a massive amount of knowledge about the genetic basis of human cancer. Culminating with the sequencing of…
At initial presentation, 20% to 30% of patients with colon and rectal cancer have detectable metastatic disease. Precise guidelines are lacking for the treatment of this special subset. Most of…
Functional outcomes of colorectal cancer treatment are an increasingly prominent interest of patients, clinicians, and researchers. The current literature on function after colorectal cancer treatment is difficult to assimilate, with…
There are an increasing number of reports on nonoperative management of rectal cancer patients who achieve a dramatic response to neoadjuvant therapy. This review discusses the current literature, and describes…
Abdominoperineal excision (APE) is a necessary operation in many patients with low rectal cancer. Outcomes after this procedure, however, have been variable and often suboptimal. With a new concept of…
Total mesorectal excision with preoperative radiation and chemotherapy provide the lowest local recurrence rates for rectal cancer. Timing of surgery after preoperative chemoradiation is being increased to optimize tumor downstaging….
Over the past several decades there have been tremendous improvements in the outcomes of patients with rectal cancer. Imaging modalities such as endorectal ultrasonography (ERUS), magnetic resonance imaging (MRI), and…
Colorectal cancer is one of the most commonly diagnosed cancers in men and women in the developed world. Although surgery is the foundation of curative treatment, adjuvant chemotherapy also improves…
