Gastric Cancer: Endoscopic Diagnosis and Staging
Gastric cancer is common and is a cause of severe morbidity and mortality. Early diagnosis can improve the chances of cure and prolong survival because prognosis is inversely related to…
ONCOLOGY
Familial Gastric Cancer: Genetics, Diagnosis, and Management
This article focuses on the diagnosis and management of familial gastric cancer, particularly hereditary diffuse gastric cancer (HDGC). First, existing consensus guidelines are discussed and then the pathology and genetics…
Gastrointestinal Stromal Tumors of the Stomach
Gastrointestinal stromal tumors (GISTs) are relatively rare mesenchymal tumors located within the submucosa of the GI tract. The defining characteristic of GISTs is the presence of the cell-surface antigen CD117…
Standard D2 and Modified Nodal Dissection for Gastric Adenocarcinoma
The quality of surgical treatment is a major determinant of cancer treatment outcomes; however, controlling surgical quality is a difficult task. Surgical treatment of gastric cancers, and especially the benefits…
Sarcomas and the Immune System: Implications for Therapeutic Strategies
Soft-tissue sarcomas are a heterogeneous group of tumors that are capable of generating host immune responses. Historically the role of antitumor immunity was first studied in soft-tissue sarcomas. Subsequent in vitro…
Improving Outcomes for Retroperitoneal Sarcomas: A Work in Progress
This article presents the current understanding of prognostic factors and outcomes for retroperitoneal sarcoma. The discussion focuses on the literature published since 2000, including studies with cohorts of at least…
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma: What Is It?
Liposarcoma (LPS) is the most common soft tissue sarcoma, frequently found in the thigh and retroperitoneum. LPS is commonly classified into well-differentiated LPS and dedifferentiated LPS. Histologic subtype, tumor location,…
Updates on the Management of Gastrointestinal Stromal Tumors
Despite being the most common sarcoma of the gastrointestinal tract, gastrointestinal stromal tumor (GIST) has been widely recognized as a unique entity for just over a decade. The advent of…
Isolated Regional Therapy for Advanced Extremity Soft Tissue Sarcomas
Patients presenting with unresectable, large, primary or recurrent extremity soft tissue sarcoma or locally advanced extremity tumors may benefit from treatment options in the form of isolated regional perfusion therapy….
Pulmonary Metastasectomy for Soft Tissue Sarcoma
The American Cancer Society predicts 10,520 new cases and 3920 deaths from soft tissue sarcoma (STS) for 2010. STS disseminates primarily via the hematogenous route, although lymphatic spread does occur…
