Towards an Intermediate Grade in Glioma Classification
Fig. 5.1 Three examples (a = case 1; b = case 2; c = case 3) of microfoci of “intermediate grade” at low magnification (left) and at high magnification (right)…
ONCOLOGY
The Genomics of Diffuse Low-Grade Gliomas
Molecular markers Prevalence (n > 1000 glioma subjects) (%) IDH mutation only 45 Triple-positive [TERTp-mut, IDH-mut, 1p/19q codeletion] 29 TERTp-mutation only 10 Triple negative [TERTp- wild type, IDH-wild type, 1p/19q…
Dissemination of Diffuse Low-Grade Gliomas: Tools and Molecular Insights
Fig. 7.1 (a) Photograph of a grade II diffuse glioma culture maintained 2 weeks after resection. (b) Detection of cells expressing the mutated form of IDH1 with R132H specific antibody….
Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Patients with Diffuse Low-Grade Gliomas
© Springer-Verlag London Ltd. 2017Hugues Duffau (ed.)Diffuse Low-Grade Gliomas in Adults10.1007/978-3-319-55466-2_1 1. Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Patients with Diffuse Low-Grade Gliomas Hugues Duffau1, 2 (1) Department…
Pathogenesis of Diffuse Low-Grade Gliomas
Type-1 Type-2 Type-3a Type-3b Clinical characteristics Age, median (IQR), y 45 (36–54) 36 (30–44) 43 (28–49) 57 (46–64) OS, mean (95% CI), y 16.38 (14.15–NA) 7.88 (6.76–9.70) 9.13 (5.05–NA)…
Minimally Invasive Surgery for Endometrial Cancer
Fig. 7.1 Surgeon’s console Fig. 7.2 Patient cart Robotic surgery enables surgeons to be more precise, advancing their technique and enhancing their capability in performing complex minimally invasive surgery. Binocular…
Diagnosis and Pre-management Workup of Endometrial Carcinoma
Fig. 5.1 Tamoxifen-induced cystic hyperplasia of the endometrium Hence, in asymptomatic women, there is a poor correlation between ultrasonographically measured endometrial thickness and abnormal pathology, and screening them has not…
Pathophysiology of Endometrial Carcinoma
Hyperplasia(typical) Simple hyperplasia without atypia Complex hyperplasia without atypia Atypical hyperplasia Simple atypical hyperplasia Complex atypical hyperplasia Fig. 4.1 Endometrium – simple hyperplasia Pathophysiology Oestrogen replacement therapy has been shown…
Endometrial Cancer: Advanced Stage
Primary tumor (T) TNM categories FIGOa stages Surgical–pathological findings TX Primary tumor cannot be assessed T0 No evidence of primary tumor Tisb Carcinoma in situ (preinvasive carcinoma) T1 I…
Recurrent Endometrial Cancer
Fig. 9.1 Anterior exenteration for a case of recurrent endometrial carcinoma treated primarily by radiation Fig. 9.2 Ileal conduit with ureteric anastomosis Fig. 9.3 Ileal conduit Fig. 9.4 Recurrence on…
