Epidemiology of Renal Cell Carcinoma
Continents Incidence Mortality North America Male 15.5 3.7 Female 8.3 1.6 Both 11.7 2.6 Europe Male 12.3 4.8 Female 5.9 1.9 Both 8.8 3.1 Oceania Male 11.0 2.8 Female 5.3…
ONCOLOGY
Forthcoming Drugs for Metastatic Renal Cell Carcinoma Therapy
Agent Molecular targets Phase (comparator) Patient population Clinical activity in RCC References Tivozanib (AV-951) VEGFR-1, 2, 3 Phase III (TIVO-1) (vs. sorafenib) Clear cell RCC PFS (11.9 vs. 9.1 mo)…
Refractory Mechanisms
© Springer Japan KK 2017Mototsugu Oya (ed.)Renal Cell Carcinoma10.1007/978-4-431-55531-5_15 15. Refractory Mechanisms Mototsugu Oya1 , Toshiaki Shinojima1 and Ryuichi Mizuno1 (1) Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan Mototsugu Oya Email:…
Treatment for Non-clear Cell Renal Cell Carcinoma
Author Study design Setting Population Treatment line Patients, n Patients with NCCRCC, n NCCRCC histologies Targeted agent Ratain et al. [5] 2 Metastatic RCC 2nd 152 15 PRCC Sorafenib Stadler…
Mammalian Targets of Rapamycin Inhibitors: Temsirolimus and Everolimus
Characteristic Temsirolimus Everolimus Study population Treatment-naive patients with poor-risk disease Patients who had progressed on prior sunitinib and/or sorafenib Number of patients 626 410 Randomization Temsirolimus vs. temsirolimus/IFN-α vs. IFN-α…
Tyrosine Kinase Inhibitors: Sorafenib, Sunitinib, Axitinib, and Pazopanib
Treatment Number of patients Line of treatment ORR (%) PFS (months) OS (months) Sorafenib vs. placebo [13, 14] 903 Second line 10 vs. 2 5.5 vs. 2.8 (p < 0.01) 17.8 vs….
Predictive and Prognostic Markers in Metastatic Renal Cell Carcinoma
Similar trial and Inclusion criteria Agents Number of patients Months (95 % IC) Number of patients Months (95 % IC) Patients receiving first-line TT mOS from patients in IMDC PFS from patients…
Surgical Treatment for Renal Cell Carcinoma
System Variables 1 pt 2 pts 3 pts RENAL Radius (maximal diameter) R ≤ 4 cm 4 < R ≤ 7 cm R ≥ 7 cm Low complexity: 4–6 Exo-/endophytic ≥50 % <50 % Endophytic Moderate complexity: 7–9 Nearness to collecting system/sinus N ≥ 7 mm 4 < N < 7 mm ≤4 mm High…
Natural History and Active Surveillance
© Springer Japan KK 2017Mototsugu Oya (ed.)Renal Cell Carcinoma10.1007/978-4-431-55531-5_7 7. Natural History and Active Surveillance Jaimin R. Bhatt1, 2, Patrick O. Richard1, 3 and Michael A. S. Jewett1 (1) Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Hospital,…
Malignant Ovarian Germ Cell Tumours: An Overview of Management and Controversies
Histological subtype AFP HCG Primitive germ cell tumours Dysgerminoma − ± Yolk sac tumour ++ − Embryonal carcinoma ± ± Polyembryona ± + Non-gestational choriocarcinoma − ++ Mixed germ…
