Targeted and Immunotherapy Agents Color Key Agents in early-stage clinical trial investigations first in man, phase 1 Agents in late-stage clinical trial investigations (phases 2 and 3) FDA-approved agents FDA-approved…
Carcinogenesis from the Perspective of Targeted Therapy and Immunotherapy Introduction In this section, we will discuss elements of cellular biology and immunology that have given insight into personalized genomically based…
Palliation INTRODUCTION Radiation therapy (RT) can be a highly effective tool for the treatment of symptoms caused by progressive gynecologic cancers. Common indications for palliative treatment of gynecologic cancers include…
Unknown Primary INTRODUCTION Most gynecologic cancers present with bleeding, pain, or other symptoms caused by an enlarging primary tumor. However, in some cases, patients are initially diagnosed when lymphadenopathy or…
Ovarian Cancer INTRODUCTION As will be shown later in this chapter, there is strong evidence that radiation therapy (RT) can play an important role in the curative treatment of selected…
Targets by Organ Site Abbreviations • CBR: clinical benefit rate (CR + PR + SD) • CR: complete response • d: days • DOR: duration of response • HR: heart…
Vulvar Cancer Before the mid-1980s, it was commonly believed that radiation therapy (RT) had no role in the curative management of vulvar cancer. Then in 1986, Homesley et al.1 reported…
Uterine Cancer INTRODUCTION Most endometrial cancers are cured by simple removal of the uterus. For this reason, investigators have tended to focus their attention on improving methods of identifying the…
Vaginal Cancer INTRODUCTION Among the gynecologic malignancies treated with radiation therapy, vaginal cancers pose some of the greatest management challenges. Several factors contribute to this: Vaginal cancer is rare. Fewer…
Cervical Cancer INTRODUCTION Invasive cervical cancer is relatively rare in developed countries, and only about 12,000 new cases are diagnosed each year in the United States.1 However, invasive cervical cancer…
