SUMMARY Print Section Listen SUMMARY When procoagulants are produced or introduced into the blood and overcome the anticoagulant mechanisms of coagulation, intravascular thrombin is generated systemically, which can lead to…

SUMMARY Print Section Listen SUMMARY Venous thromboembolism, consisting of deep vein thrombosis and/or pulmonary embolism, is a common disorder with an estimated 900,000 patients each year in the United States…

SUMMARY Print Section Listen SUMMARY Improved understanding of the molecular mechanisms of fibrinolysis has led to major advances in fibrinolytic and antifibrinolytic therapy. Characterization of the genes for all the…

SUMMARY Print Section Listen SUMMARY The antiphospholipid (aPL) syndrome (APS) is an acquired thrombophilic disorder in which patients have vascular thrombosis and/or pregnancy complications attributable to placental insufficiency, accompanied by…

SUMMARY Print Section Listen SUMMARY Thrombotic microangiopathy is a general term for the combination of micro­angiopathic hemolytic anemia and thrombocytopenia, often accompanied by signs and symptoms consistent with disseminated microvascular…

SUMMARY Print Section Listen SUMMARY von Willebrand factor (VWF) is a central component of hemostasis, serving both as an adhesive link between platelets and the injured blood vessel wall and…

SUMMARY Print Section Listen SUMMARY Thrombophilia refers to laboratory abnormalities that increase the risk of venous thromboembolism (VTE). Over the past several decades, numerous factors have been identified. The most…

SUMMARY Print Section Listen SUMMARY The approximately 1 trillion platelets that circulate in an adult human are small anucleate cell fragments adapted to adhere to damaged blood vessels, to aggregate…