Fibrinolysis and Thrombolysis
SUMMARY Print Section Listen SUMMARY Improved understanding of the molecular mechanisms of fibrinolysis has led to major advances in fibrinolytic and antifibrinolytic therapy. Characterization of the genes for all the…
ONCOLOGY
The Antiphospholipid Syndrome
SUMMARY Print Section Listen SUMMARY The antiphospholipid (aPL) syndrome (APS) is an acquired thrombophilic disorder in which patients have vascular thrombosis and/or pregnancy complications attributable to placental insufficiency, accompanied by…
Thrombotic Microangiopathies
SUMMARY Print Section Listen SUMMARY Thrombotic microangiopathy is a general term for the combination of microangiopathic hemolytic anemia and thrombocytopenia, often accompanied by signs and symptoms consistent with disseminated microvascular…
von Willebrand Disease
SUMMARY Print Section Listen SUMMARY von Willebrand factor (VWF) is a central component of hemostasis, serving both as an adhesive link between platelets and the injured blood vessel wall and…
Hereditary Thrombophilia
SUMMARY Print Section Listen SUMMARY Thrombophilia refers to laboratory abnormalities that increase the risk of venous thromboembolism (VTE). Over the past several decades, numerous factors have been identified. The most…
Platelet Morphology, Biochemistry, and Function
SUMMARY Print Section Listen SUMMARY The approximately 1 trillion platelets that circulate in an adult human are small anucleate cell fragments adapted to adhere to damaged blood vessels, to aggregate…
Hemostatic Alterations in Liver Disease and Liver Transplantation
SUMMARY Print Section Listen SUMMARY In patients with acute liver failure or chronic liver disease, many changes in the hemostatic system occur. The liver is the site of synthesis of…
Antibody-Mediated Coagulation Factor Deficiencies
SUMMARY Print Section Listen SUMMARY Clinically significant autoantibodies to coagulation factor deficiencies are uncommon but can produce life-threatening bleeding and death. The most commonly targeted coagulation factor in autoimmunity is…
Hereditary Fibrinogen Abnormalities
NOTE Print Section Listen The authors thank Dr. Alessandro Casini for helpful comments and suggestions. SUMMARY Print Section Listen SUMMARY Hereditary fibrinogen abnormalities make up two classes of plasma fibrinogen…
Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIII
NOTE Print Section Listen The authors would like to thank Dr. U. Selighson and Dr. O. Salomon for their contributions to this chapter. SUMMARY Print Section Listen SUMMARY Rare bleeding…
