Noncutaneous Melanoma
INTRODUCTION Print Section Listen During embryogenesis, melanocytes migrate from the neural crest and eventually are widely distributed throughout skin, mucosa, and other sites. Melanomas arising in noncutaneous sites are a…
ONCOLOGY
Surgical Management of Metastatic Melanoma (Stage III and IV Disease)
INTRODUCTION Print Section Listen This chapter describes the indications for surgery, technical aspects of surgery, and outcomes for patients with metastatic melanoma involving regional lymph nodes (stage III) or distant…
The Surgical Management of Locoregionally Recurrent and in-Transit Melanoma
TREATMENTS DIRECTED AT LOCOREGIONAL RECURRENCE AND IN-TRANSIT METASTASES Print Section Listen Locoregional recurrence of a melanoma is defined as recurrence in or around a scar from previous melanoma surgery, or…
Sentinel Lymph Node Biopsy for Melanoma
INTRODUCTION Print Section Listen Sentinel lymph node (SLN) biopsy is now a standard component of the treatment of many melanomas, and its use is accepted as routine.1,2 So routine, in…
Biopsy and Definitive Excision of Primary Cutaneous Melanomas
BIOPSY Print Section Listen A skin lesion that is suspicious for melanoma is best removed by excisional biopsy with a 1- to 2-mm clinical lateral margin and a deep margin…
Regional Cancer Therapy: Isolation Perfusion, Isolation Infusion, and Local Ablative Techniques
INTRODUCTION Print Section Listen Regional cancer therapies are treatments that direct a therapeutic intervention to a cancer burdened organ or region of the body; they have the collective advantage of…
Genomics and Cancer Biomarkers
INTRODUCTION Print Section Listen Cancer is a complex disease capable of manifesting itself as many different disease phenotypes occurring in virtually any tissue of the body. This complexity can be…
Cancer Epigenetics
“EPIGENETICS”: ORIGIN OF THE WORD Print Section Listen Conrad Hal Waddington is usually credited with modifying the Greek word “epigenesis,” which described a theory of development, into a new term…
Radiation Oncology: Concepts and Techniques
EXTERNAL BEAM RADIATION THERAPY Print Section Listen Radiation Oncology is the medical discipline that uses ionizing radiation with therapeutic intent in the management of cancer and selected benign disease. Compared…
