Chronic Graft-Versus-Host Disease
Organ or site Diagnostic (adequate for the diagnosis of cGvHD) Distinctive (seen in cGvHD but not aGvHD; insufficient to establish cGvHD diagnosis) Other features (cannot be used to establish a…
HEMATOLOGY
Oral Complications
Grade WHOa NCI-CTCb Bearman Grade 0 No oral abnormalities No oral abnormalities No oral abnormalities Grade 1 Oral soreness +/− erythema without ulceration; able to tolerate regular diet Erythema Pain…
Gastrointestinal Complications
Grade Diarrhea 1 Increase of < 4 stools per day over baseline; mild increase in ostomy output compared to baseline 2 Increase of 4–6 stools per day over baseline; IV fluid…
The Business of Cellular Therapy and Hematopoietic Stem Cell Transplantation
Fig. 2.1 Estimated annual numbers of transplants in the USA were compiled according to the number registered with CIBMTR. Estimates of how closely the numbers reported are representative of actual…
Follow-Up Care
– Day 100 evaluation Additional evaluation Aplastic anemia Bone marrow biopsy/aspirate for path, flow, and FISH for MDS panel EBV titers monthly posttransplant × 12 months – Chimerismsa – – CBC…
Engraftment
Major criteria Minor criteria T ≥ 38.3 °C with no identifiable infectious etiology Hepatic dysfunction with either total bilirubin ≥ 2 mg/dL or transaminase levels ≥ 2x ULN Erythrodermatous rash involving > 25 % BSA and not…
Transfusion Medicine
Suspected TRALI Acute onset within 6 h of blood transfusion PaO2/FiO2 < 300 mmHg, or worsening of P to F ratio Bilateral infiltrative changes on chest radiograph No sign of hydrostatic pulmonary edema…
Antithrombotic Guidelines
Aspirin – Primary prevention Stop Secondary prevention Stop during conditioning, resume when platelets > 50,000 Coronary stent – Bare metal Combined therapy (ASA = aspirin + P2Y12 Inhibitor) 4 weeks, then ASA thereafter….
Graft-Versus-Host Disease Prophylaxis
Creatinine (mg/dL) Cyclosporine/tacrolimus dose 1.5–1.75 (or 1–1.5 × baseline) 50–75 % of current dose 1.76–2 (or 1.6–1.9 × baseline) 25–50 % of current dose > 2 (or > 1.9 × baseline) Hold until creatinine < 2 then resume…
Infection Prophylaxis
VZV−/HSV− VZV−/HSV+ VZV+/HSV−/+ Autologous No prophylaxis required Acyclovir 800 mg po daily through day + 365 Acyclovir 800 mg po daily through day + 365 Allogeneic No prophylaxis requireda Acyclovir 800 mg po BID…
