The Lung–Blood Interface
Fig. 1.1 Diagram of the human airway system . There are 23 generations of branching airways on average, beginning with larger airways in the conducting zone, consisting of the trachea…
HEMATOLOGY
Transfusion and Acute Respiratory Distress Syndrome: Clinical Epidemiology, Diagnosis, Management, and Outcomes
Mechanisms of TRALI Two pathophysiologic mechanisms of TRALI have been recognized, immune-mediated TRALI and non-antibody mediated TRALI. Anywhere from 65 to 90 % of reported cases are found to be…
Bleeding Disorders: Diagnosis and Treatment of Hemorrhagic Complications in the Intensive Care Unit
VWF:Ag VWF:RCo VWF:RCo/VWF:Ag FVIIII Multimer pattern LD-RIPA Platelet count Other specialized testing Type 1 Mild decrease Mild decrease >0.5–0.7 Normal or mild decrease Normal Absent Normal Type 1C Mild…
Treatment of Non-criteria Manifestations in Antiphospholipid Syndrome
Figs. 13.1 and 13.2 Antiphospholipid antibody-associated skin ulcers Expert Opinion 1 (Paulo Ricardo Criado, Dermatology) Livedoid vasculopathy is a recurrent painful ulcerative disorder, on the skin of the lower extremities,…
Origin of Antiphospholipid Antibodies
Infectious agent APS manifestations Staphylococcus aureus CAPS [142] Streptococcus pyogenes Cardiac valve and CNS lesions [133, 137] Escherichia coli CAPS [143] Klebsiella CAPS [144] Hepatitis C Thrombosis, brain infarction [145]…
Mechanisms of Antiphospholipid Antibody-Mediated Pregnancy Morbidity
Fig. 6.1 Blocking the actions of antiphospholipid antibodies (aPL). (A) The monoclonal antibody, N11, prevents the actions of aPL on trophoblast and endothelial cells and attenuates aPL-associated pregnancy complications and…
Mechanisms of Antiphospholipid Antibody-Mediated Thrombosis
Model (order determined by date of first published report) Notes on pathophysiology Protective interventions Femoral vein pinch injury (mouse): injection of patient aPL, followed by a standard pinch injury to…
Definition and Epidemiology of Antiphospholipid Syndrome
Clinical criteria 1. Vascular thrombosis One or more clinical episodes of arterial, venous, or small vessel thrombosis, in any tissue or organ. Thrombosis must be confirmed by objective validated criteria…
15th International Congress on Antiphospholipid Antibodies Task Force on Catastrophic Antiphospholipid Syndrome Report
Clinical manifestation % Organ involved Kidney 73 Renal failure 77 Proteinuria 29 Arterial hypertension 24 Hematuria 16 Lung 60 Acute respiratory distress syndrome 36 Pulmonary embolism 26 Alveolar hemorrhage…
15th International Congress on Antiphospholipid Antibodies Task Force on Antiphospholipid Syndrome Treatment Trends Report
© Springer International Publishing AG 2017Doruk Erkan and Michael D. Lockshin (eds.)Antiphospholipid Syndrome10.1007/978-3-319-55442-6_18 18. 15th International Congress on Antiphospholipid Antibodies Task Force on Antiphospholipid Syndrome Treatment Trends Report Danieli Andrade1 , Ricard Cervera10, Hannah Cohen11, Mark Crowther12, Maria J. Cuadrado13, Guillaume Canaud14, David A. Garcia15,…
