Overview of Vascular Biology
Overview of Vascular Biology William C. Aird OVERVIEW OF VASCULAR BIOLOGY The coagulation system has evolved to prevent excessive blood loss at sites of vascular injury. As much as the…
HEMATOLOGY
Blood-Borne Microparticles
Blood-Borne Microparticles JosÉ A. LÓPez Swaminathan Murugappan This chapter concerns a blood element that has not been specifically addressed in previous editions of this textbook: bloodborne cell-derived microparticles. Although microparticles…
The Role of Platelets in Blood Coagulation
The Role of Platelets in Blood Coagulation Peter N. Walsh The hemostatic response to vascular injury consists of a series of proteolytic reactions that occur on the surface of activated…
Platelet Prostanoid Metabolism
Platelet Prostanoid Metabolism Tilo Grosser Garret A. Fitzgerald The prostanoids, which include prostaglandins (PGs) and thromboxane (TX) A2, are a series of lipid hormones that act on specific G-protein-coupled receptors…
Platelet Signal Transduction
Platelet Signal Transduction Charles S. Abrams Lawrence F. Brass Platelets become activated when agonists such as collagen or thrombin bind to receptors on the platelet surface, initiating intracellular signaling events…
Molecular Basis for Platelet Secretion
Molecular Basis for Platelet Secretion Shaojing Ye Sidney W. Whiteheart INTRODUCTION Platelets are small, anucleate, discoid cell fragments produced by bone marrow megakaryocytes. Structurally, platelets are simple, containing plasma membrane…
Integrín αIIbβ3 and Platelet Aggregation
Integrín αIIbβ3 and Platelet Aggregation Ana Kasirer-Friede Kamila Bledzka Jun Qin Edward F. Plow Sanford J. Shattil PERSPECTIVE In 1977, Phillips and Agin1 provided important insight into the hemostatic function…
Platelet Collagen Receptors
Platelet Collagen Receptors Stephen P. Watson Richard W. Farndale Masaaki Moroi Stephanie M. Jung Platelets, small anucleate circulating blood cells, are known to be activated by several physiologic substances, including…
Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis
Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis David L. Bark Jr. Warwick S. Nesbitt Angus K.T. Wong Shaun P. Jackson The hemodynamic effects of…
The Basis for Platelet Adhesion
The Basis for Platelet Adhesion Brian Savage Zaverio M. Ruggeri PERSPECTIVE Mammalian platelets are circulating fragments of bone marrow megakaryocytes1,2 that function primarily to maintain the integrity of the vasculature…
