Laboratory Markers of Platelet Activation Paul Harrison Alan D. Michelson Prevention of platelet activation in the intact circulation is normally controlled by the antithrombotic nature of the endothelial cell surface,…
Acquired Disorders of Platelet Function A. Koneti Rao Joel S. Bennett Platelets are essential for normal hemostasis. Thus, defects in platelet function may lead to bleeding diatheses. Platelet function defects…
Inherited Disorders of Platelet Function Joel S. Bennett A. Koneti Rao Prolongation of the bleeding time in a patient with a normal platelet count suggests the presence of either von…
Acquired Nonimmune Thrombocytopenia Andreas Greinacher Theodore E. Warkentin Acquired thrombocytopenic disorders can be divided into five categories, plus the spurious entity of pseudothrombocytopenia (Table 64.1): hemodilution, sequestration (usually due to…
Inherited Thrombocytopenias Paquita Nurden Alan T. Nurden Bleeding syndromes arising from an inherited defect of platelet production are an important group of rare diseases with a variety of causes.1,2,3,4 Some,…
Drug-Induced Thrombocytopenia Richard H. Aster James N. George BACKGROUND Drugs induce thrombocytopenia through various mechanisms. The inhibition of platelet production is an expected result of the dose-dependent toxicity of chemotherapeutic…
Immune Thrombocytopenia and Posttransfusion Purpura Howard A. Liebman Douglas B. Cines James B. Bussel IMMUNE THROMBOCYTOPENIA Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by thrombocytopenia with or without…
Differential Diagnosis of Thrombocytopenia Joel S. Bennett Charles S. Abrams Thrombocytopenia is encountered frequently in clinical practice, engendering substantial and appropriate concern about its etiology and the consequent risk and…
Overview of Acquired and Inherited Clinical Platelet Disorders Joel S. Bennett An insufficient number of platelets (thrombocytopenia) or impaired platelet function (thrombocytopathia) can produce bleeding. Both situations are encountered frequently…
Laboratory Markers of Activated Coagulation and Its Regulation Kenneth A. Bauer Helen A. Ireland The development of blood tests to predict thrombotic events, or to confirm or exclude the presence…
