HEMATOLOGY
Future Directions and Targeted Therapies in Bladder Cancer
There are substantial unmet needs for patients with metastatic urothelial carcinoma (UC). First-line cisplatin-based chemotherapy regimens yield a median survival of 12 to 15 months and long-term survival in 5% to…
Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer
Recent studies revealed that muscle-invasive bladder cancers segregate into intrinsic basal and luminal subtypes that are similar to those described for breast cancer. Each subtype is enriched with potentially clinically…
Second-Line Therapies in Metastatic Urothelial Carcinoma
Patients with relapsed or refractory urothelial carcinoma (UC) face a poor prognosis and a dearth of available treatment options that improve their survival. End-organ function and performance status play a…
First-line Treatment of Metastatic Disease
More than 50% of patients with advanced urothelial carcinoma are not eligible for the standard treatment with cisplatin-based chemotherapy. In general, cisplatin-ineligible patients with metastatic urothelial cancer experience poor outcomes…
Perioperative Therapy for Muscle Invasive Bladder Cancer
Muscle invasive bladder cancer (MIBC) is an aggressive disease associated with poor survival rates. High rates of relapse, despite radical cystectomy, suggest that administration of systemic therapy in the perioperative…
First-Line Treatment and Prognostic Factors of Metastatic Bladder Cancer for Platinum-Eligible Patients
Metastatic urothelial carcinoma is primarily a disease of the elderly, with a median overall survival of approximately 15 months. Cisplatin-based combination chemotherapy is standard first-line treatment for eligible patients, with…
Bladder Preservation Strategies
Although cystectomy remains the standard for treatment of muscle-invasive bladder cancer in the United States, there exist potentially curative alternatives for a selected subset of these patients in organ preservation…
New Trends in the Surgical Management of Invasive Bladder Cancer
Radical cystectomy with urinary diversion is one of the most complex urologic procedures and is associated with significant morbidity and mortality. Although it remains the gold standard for treatment of…
Diagnosis and Management of Upper Tract Urothelial Carcinoma
While UTUC is relatively uncommon, it has an aggressive natural history and poor prognosis, which has not substantially improved over the past two decades. Nevertheless, continued research has led to…
