Abstract Childhood non-Hodgkin lymphoma (NHL) is distinguished from adult NHL by differing frequencies of histopathologic types and by the greater frequency of extranodal presentations. With current combination chemotherapy regimens, survival…
Abstract This chapter describes the causes, clinical manifestations, diagnosis, and treatment of various types of histiocytosis disorders. Keywords Histiocytosis, Langerhans cell histiocytosis, Rosai–Dorfman disease, emophagocytic lymphohistiocytosis, Erdheim–Chester disease, Hand–Schüller–Christian disease,…
Abstract Hodgkin lymphoma is characterized by progressive enlargement of lymph nodes. It is considered unicentric in origin and has a predictable pattern of spread by extension to contiguous nodes. Keywords…
Abstract Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood with a peak incidence between 2 and 6 years of age. Recent advances in understanding the leukemia biology,…
Abstract Acute myeloid leukemia (AML) accounts for approximately 20% of childhood leukemia, yet is responsible for a majority of the deaths from leukemia. Children present with a wide range of…
Abstract Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders characterized by varying degrees of cytopenias secondary to ineffective and dysplastic hematopoiesis and increased propensity to evolve into acute myeloid…
Abstract Lymphoproliferative disorders manifest with uncontrolled hyperplasia of lymphoid tissues (lymph nodes, spleen, bone marrow, liver). They are a heterogeneous group of diseases that range from reactive polyclonal hyperplasia (immunologic…
Abstract In this chapter, we introduce the concept of hemolytic anemia and classify them into corpuscular defects due to abnormalities in membrane, enzymes or hemoglobin and extracorpuscular defects due to…
Abstract This chapter describes the physiology of hemostasis including platelet plug formation, platelet vessel interaction, coagulation cascade and fibrinolysis; diagnosis and management of von Willebrand disease; inherited and rare bleeding…
Abstract This chapter describes the causes, clinical manifestatilons, diagnosis, and treatment of various quantitative disorders of white blood cells, both inherited and acquired. It also discusses disorders of white cell…
