Precautions: Sustained hypotension may occur. Keep patient supine throughout testing. Patients may experience dry mouth or drowsiness [1] Interpretation: Criteria for diagnosis of pheochromocytoma : 3 h after clonidine; one of…

Assay for Aldosterone: Enzymatic Radioimmunoassay (RIA). Precautions: Do not perform this test in patients with severe uncontrolled hypertension, renal insufficiency, cardiac insufficiency, cardiac arrhythmia, or severe hypokalemia [1]. Interpretation: With…

Assay for Cortisol: Chemiluminescence immunoassay (CLIA) . Precautions: Cosyntropin is category C of pregnancy. Interpretation: Normal response: Peak stimulated cortisol value > 18 mcg/dl at 30 min [1, 2]. Most patients achieve higher…

© Springer International Publishing Switzerland 2015Ahmet Bahadir Ergin, A. Laurence Kennedy, Manjula K. Gupta and Amir H. HamrahianThe Cleveland Clinic Manual of Dynamic Endocrine Testing10.1007/978-3-319-13048-4_7 7. Overnight Low Dose Dexamethasone Suppression Test—1 mg Ahmet Bahadir Ergin1  , Amir H. Hamrahian1  , A….

Day Date What to do 1 Day and date Have labs (thyroglobulin) drawn Related posts: Metyrapone Stimulation Test Ovine Corticotropin-Releasing Hormone (oCRH) Stimulation Test Insulin Tolerance Test (ITT) GHRH–Arginine GH…

Sample ACTH (pg/mL) Prolactin (ng/mL) Cortisol (µg/mL)  Petrosal sinus Petrosal sinus  Peripheral Right Left ACTH ratio Peripheral Right Left Prolactin ratio Peripheral     R/P L/P R/L    R/P L/P   ADH (− 10 min)              ADH…

Precautions: Do not leave the patient unattended since hypoglycemia is expected. A physician must be available in the walking distance from the room where the ITT is performed. Interpretation: A…

2. Bruno OD, Rossi MA, Contreras LN, et al. Nocturnal high-dose dexamethasone suppression test in the aetiological diagnosis of Cushing’s syndrome. Acta Endocrinol (Copenh). 1985;109(2):158–62. 3. Dichek HL, Nieman LK, Oldfield…

Assay for GH: Immunoenzymatic assay Precautions: Patients may complain of nausea. Interpretation: Diagnosis of acromegaly: Using ultrasensitive assays, a GH suppression to < 0.4 ng/ml is considered the gold standard test to…

Assay for Cortisol: Chemiluminescence Immunoassay (CLIA) . Precautions: None. Interpretation: Serum cortisol concentration > 1.4–1.8 µg/dl after 2 day low dose dex is strongly suggestive of Cushing’s syndrome [1]. Caveats: Use of…