Blood Management in the Cardiovascular Surgical Patient
Blood Management in the Cardiovascular Surgical Patient Lawrence Tim Goodnough L. Henry Edmunds Jr. Bleeding is a potential complication of any surgery and a major concern of all surgeons. All…
Hemostatic Abnormalities in Renal Disease
Hemostatic Abnormalities in Renal Disease Miriam Galbusera Giuseppe Remuzzi Patrizia Ondei Patients with renal disease suffer from complex hemostatic abnormalities leading to two opposite complications: bleeding tendency and thrombotic risk….
Hemostatic Challenges in Liver Disease
Hemostatic Challenges in Liver Disease Charles S. Eby Stephen H. Caldwell The liver is the predominant site for synthesis and clearance of proteins involved in formation and lysis of fibrin,…
Cancer-Related Thrombosis
Cancer-Related Thrombosis Anna Falanga Agnes Y. Y. Lee Frederick R. Rickles The close association between malignant disease and thrombosis is well known and was first described more than a century…
Hemorrhagic Fevers: Epidemiology, Pathophysiology, and Clinical Features
Hemorrhagic Fevers: Epidemiology, Pathophysiology, and Clinical Features L. Gayani Tillekeratne Jennifer Cohn Hillary Dunlevy HEMORRHAGIC FEVERS Background Hemorrhagic fevers (HF) refer to illnesses largely caused by several distinct classes of…
Thrombohemorrhagic Complications of Sepsis
Thrombohemorrhagic Complications of Sepsis Marcel Levi Sepsis is a clinical syndrome that is caused by an infection, often associated with bacteremia and characterized by the presence of systemic signs and…
Thrombotic Complications of Sickle Cell Disease
Thrombotic Complications of Sickle Cell Disease Kenneth I. Ataga Elliott P. Vichinsky In addition to its well described vaso-occlusive and hemolytic complications, patients with sickle cell disease (SCD) are at…
Venous and Arterial Thromboembolism in Children
Venous and Arterial Thromboembolism in Children Paul Monagle M. Patricia Massicotte Anthony K. Chan INTRODUCTION Thromboembolic disease in infancy and childhood has been described as a new epidemic of tertiary…
Bleeding in Neonates and Children
Bleeding in Neonates and Children Anthony K. C. Chan Elizabeth A. Chalmers Sam Schulman Alan D. Michelson Neonates and children may be born with a congenital bleeding disorder or they…
Developmental Hemostasis
Developmental Hemostasis Paul Monagle Vera Ignjatovic Leslie Roy Berry Hemostasis is a complex homeostatic system that is critical to maintaining healthy life. Disturbances of the hemostatic system account for a…
