Oncogenic Viruses
Oncogenic Viruses Christopher B. Buck Lee Ratner PRINCIPLES OF TUMOR VIROLOGY Viral infections are estimated to play a causal role in at least 11% of all new cancer diagnoses worldwide.1…
Molecular Methods in Cancer
Molecular Methods in Cancer Larissa V. Furtado Jay L. Hess Bryan L. Betz APPLICATIONS OF MOLECULAR DIAGNOSTICS IN ONCOLOGY Molecular diagnostics is increasingly impacting a number of areas of cancer…
Hallmarks of Cancer: An Organizing Principle for Cancer Medicine
Hallmarks of Cancer: An Organizing Principle for Cancer Medicine Douglas Hanahan Robert A. Weinberg INTRODUCTION The hallmarks of cancer comprise eight biologic capabilities acquired by incipient cancer cells during the…
The Cancer Genome
The Cancer Genome Yardena Samuels Alberto Bardelli Jared J. Gartner Carlos López-Otin INTRODUCTION There is a broad consensus that cancer is, in essence, a genetic disease, and that accumulation of…
Epstein-Barr Virus
Epstein-Barr Virus Amit Kalra Jonathan P. Moorman INTRODUCTION Epstein-Barr virus (EBV) belongs to the family of gamma herpesviridae. EBV is a double-stranded DNA lymphocytotropic virus that induces both latent and…
Fever of Unknown Origin
Fever of Unknown Origin Amit Kalra Jonathan P. Moorman DEFINITION Fever of unknown origin (FUO) was defined by Petersdorf and Beeson in 1962: 1. Temperature of >101°F (38.3°C) on several…
Lymphadenopathy and Fever
Lymphadenopathy and Fever Jonathan P. Moorman Generalized lymphadenopathy with associated fever is a symptom complex common to many different disease entities. Persistent generalized lymphadenopathy is defined as two or more…
Neutropenic Fever
Neutropenic Fever Susan Harwell Ashley Tyler Christopher Trabue INTRODUCTION With the advent of cytotoxic chemotherapy for both acute leukemia and solid organ tumors over the past half century, the landscape…
