Mechanisms of Immune-Related Adverse Events
Introduction ■ The origins of immunotherapy can be traced back to the early 1900s when Paul Ehrlich postulated that the host immune system plays a role in the early recognition…
Cardiovascular Toxicities of Targeted Therapy
Introduction Cardiotoxicity is one of the worrisome side effects of cancer-directed therapy. Cardiac adverse events can range from mild to severe and vary between classes of targeted agents. Some relevant…
Dermatological Toxicities of Targeted Therapy
Introduction Targeted therapies are a rapidly expanding group of anticancer drugs, which promise to provide better tolerated and higher efficacy medications compared with conventional systemic chemotherapy. Inhibition of novel pathways…
Pulmonary Toxicities of Targeted Therapy
Introduction Prior to the 1990s, cytotoxic chemotherapy was used uniformly for all malignancies. This resulted in heterogeneous responses even within a specific tumor type. As insight was gained about the…
Gastrointestinal Toxicities of Targeted Therapy
Introduction Targeted therapies are a category of drugs that inhibit cancer by interfering with specific molecules involved in the growth, progression, and spread of malignant cells. Targeted therapies act on…
Mechanisms of Toxicities Associated With Targeted Therapy
Introduction Over the last several years, molecularly targeted therapy has emerged as a new generation of cancer treatment and has been integrated into treatment protocols of many hematologic and solid…
Cancer Treatment Infusion Reactions
Introduction Cancer treatments have the potential to cause infusion reactions (IRs). It is important to manage IRs because they may cause treatment disruption and require costly medical interventions. Both cytotoxic…
Cardiovascular Toxicities of Chemotherapy
Introduction Cardiotoxic effects of chemotherapy are challenging in nature, since myocardial tissue possesses limited regenerative capacity, which renders the heart susceptible to transient and permanent side effects of chemotherapy agents….
Dermatological Toxicities of Chemotherapy
Introduction Chemotherapy can affect skin in various ways, and several chemotherapeutic agents have been linked to distinctive cutaneous side effects. Although these side effects are rarely life-threatening, they can cause…
Mechanisms of Cancer-Directed Therapies
Mechanisms of Cancer-Directed Therapies Cancer has been prevalent for centuries and humans have been concerned with the treatment of cancer for a seemingly equal time. Breast cancer was first described…
