Local-Regional Therapy following Systemic Treatment Thomas A. Buchholz Kelly K. Hunt INTRODUCTION The sequencing of systemic treatments prior to performing definitive breast cancer surgery has become increasingly common. This approach,…
Pathologic Assessment of Treatment Response after Neoadjuvant Therapy Sunati Sahoo Susan Carole Lester INTRODUCTION Neoadjuvant therapy (NAT) reveals the response of cancers to therapy in vivo and, thus, generates a…
Preoperative Endocrine Therapy for Operable Breast Cancer Ian E. Smith INTRODUCTION Preoperative estrogen therapy was first described more than 50 years ago for postmenopausal women with large and sometimes locally…
Preoperative Chemotherapy for Operable Breast Cancer Aditya Bardia José Baselga INTRODUCTION Preoperative chemotherapy, also referred to as neoadjuvant chemotherapy or primary systemic therapy, today constitutes one of the standards of…
Adjuvant Systemic Therapy Treatment Guidelines C. Kent Osborne Adjuvant therapy decisions have become more complicated as breast cancers are further subdivided into groups that mandate different treatment approaches. Division of…
Long-Term and Late Effects of Primary Curative Intent Therapy: Neurocognitive, Cardiac, and Secondary Malignancies Rena D. Callahan Patricia A. Ganz The number of women living in the United States with…
Management of Menopausal Symptoms in Breast Cancer Survivors Daniela Stan Dawn Hershman Charles L. Loprinzi INTRODUCTION In the United States today, approximately 2.7 million women live as breast cancer survivors,…
Lifestyle Issues in Breast Cancer Survivors Jennifer A. Ligibel Rowan T. Chlebowski Evidence increasingly suggests that lifestyle factors such as diet, physical activity, and body weight may play an important…
Implications of Obesity in Breast Cancer Ayca Gucalp Patrick G. Morris Clifford A. Hudis Andrew J. Dannenberg INTRODUCTION Obesity is a major risk factor for the development of some of…
Pharmacogenomics of Systemic Therapy James M. Rae INTRODUCTION TO PHARMACOGENETICS AND PHARMACOGENOMICS Over the past half century, a large number of studies on the genetic diversity of human drug response…
