B-Cell Chronic Lymphoid Leukemias
In healthy adults and older children, the majority of circulating lymphocytes in the blood are T cells (approximately 70% of lymphocytes) with fewer B cells (25%) and natural killer (NK)…
Indolent and Aggressive B-Cell Lymphoma
Introduction Non-Hodgkin B-cell lymphomas are the seventh most common malignant neoplasm and account for approximately 4% of all cancers, according to the American Cancer Society, with approximately 77,000 cases anticipated…
Transfusion Medicine and Cellular Therapy
Blood Collection In the United States, 14.2 million red blood cells and whole blood donations and approximately 2.4 million apheresis and whole blood–derived platelets were collected in 2013. Although whole…
Indolent and Aggressive Mature T-Cell and Natural Killer–Cell Lymphomas
T-Cell and Natural Killer–Cell Neoplasms With Primarily Leukemic Involvement T-Cell Prolymphocytic Leukemia Overview and Incidence T-cell prolymphocytic leukemia (T-PLL) is an aggressive, mature T-cell malignancy affecting predominantly older adults and…
Childhood Hematopoietic Disorders
General Overview and Incidence Pediatric hematology/hematopathology spans the spectrum of benign, malignant, and neoplastic mimickers. Neoplastic lymphoid, myeloid, and histocytic neoplasms follow criteria in the updated World Health Organization (WHO)…
Posttransplant Lymphoproliferative Disorders and Immunodeficiency
General Overview and Incidence Incidence varies depending on the institution, patient population, allograph types, and immunosuppression regimes. Etiology/Histopathology Clinical settings causing immune dysfunctions, such as viral Epstein-Barr virus (EBV) infection,…
Hemophilia
General Overview and Incidence Overview of Hemophilia The hemophilias are bleeding disorders caused by the absence or decrease of factor VIII in hemophilia A or factor IX in hemophilia B….
Myeloma and Related Conditions
General Overview and Incidence Multiple myeloma (MM) is a malignancy of clonal plasma cells and is part of a spectrum of plasma cells disorders encompassing the benign asymptomatic condition monoclonal…
Precursor Lymphoid Neoplasms
General Overview and Incidence Precursor lymphoid neoplasms or acute lymphoblastic leukemia (ALL) is the second most common leukemia affecting adults with about 1.6 per 100,000 and 6500 cases per year…
Myelodysplastic Syndromes
General Overview Myelodysplastic syndromes (MDSs) represent a heterogeneous group of myeloid neoplasms characterized by abnormal differentiation and maturation of myeloid cells, ineffective hematopoiesis, and increased risk of transformation to acute…
