♦Doxorubicin Hydrochloride Liposome (dox-oh-roo’-bih-sin) Doxil Pregnancy Category D Mechanism of Action The active ingredient is doxorubicin hydrochloride, which exerts its cytotoxic effect by binding DNA and inhibiting nucleic acid synthesis….
♦Doxorubicin Hydrochloride (dox-oh-roo‘-bih-sin) Adriamycin Pregnancy Category D Mechanism of Action Doxorubicin is an anthracycline antibiotic that binds to nucleic acids by intercalating with the DNA double helix. Indications ♦ Acute…
♦Docetaxel (doh-see-tax’-el) Taxotere Pregnancy Category D Mechanism of Action Docetaxel belongs to the taxoid family and acts by disrupting the microtubular network in the cells, which is essential for their…
♦Diethylstilbestrol Diphosphate (diey-e-thil-stil-bes’-trol) Stilphostrol Pregnancy Category D Mechanism of Action Unknown. Diethylstilbestrol is an estrogen that affects the hormonal milieu of the body. Indications ♦ Inoperable prostate cancer ♦ Postmenopausal…
♦Dexrazoxane (dex-ra’-zoo-zayne) Zinecard Pregnancy Category C Mechanism of Action Dexrazoxane is a chelating agent that interferes with iron-mediated radicals thought to be responsible for anthracycline-induced cardiotoxicity. Indications Reduction of the…
♦Daunorubicin Hydrochloride (daw-no-roo’ bi-sin) Cerubidine, Rubidomycin Hydrochloride Pregnancy Category C Mechanism of Action Daunorubicin is a cytotoxic, anthracycline antibiotic that inhibits the synthesis of DNA. It has antimitotic and immunosuppressive…
♦Dactinomycin (dak-tee-no-my’-seen) Actinomycin, Cosmegen Pregnancy Category C Mechanism of Action Dactinomycin is a cell cycle-nonspecific, antitumor antibiotic that interferes with RNA synthesis. Indications ♦ Wilms’ tumor ♦ Rhabdomyosarcoma ♦ Ewing’s…
♦Dacarbazine (de-kar’-ba-zeen) DTIC-Dome Pregnancy Category C Mechanism of Action The activity may be the result of three mechanisms: alkylation, antimetabolite activity as a purine precursor, and interaction with sulfhydryl groups…
♦Cytarabine (cye-tar’-a-been) ARA-C, cytosine arabinoside, Cytosar-UR Pregnancy Category D Mechanism of Action Cytarabine is a cell cycle-specific (S phase) antimetabolite that inhibits cell development from the G1 to the S…
♦Cyclophosphamide (cy-klo-foss’-fa-mide) Cytoxan, Neosar Pregnancy Category D Mechanism of Action Cyclophosphamide is a cell cycle-nonspecific nitrogen mustard derivative that acts as an alkylating agent by interfering with DNA replication and…
